Antivenom activity of triterpenoid (C34H68O2) from Leucas aspera Linn. against Naja naja naja venom induced toxicity: Antioxidant and histological study in mice

VENKATESAN, C ; SARATHI, M ; et al.

In: Human & experimental toxicology, Jg. 33 (2014), Heft 4, S. 336-359

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The isolated and identified triterpenoid, 1-hydroxytetratriacontane-4-one (C34H68O2), obtained from the methanolic leaf extract of Leucas aspera Linn. was explored for the first time for antisnake venom activity. The plant (L aspera Linn.) extract significantly antagonized the spectacled cobra (Naja naja naja) venom induced lethal activity in a mouse model. It was compared with commercial antiserum obtained from King Institute of Preventive Medicine (Chennai, Tamil Nadu, India). N. naja naja venom induced a significant decrease in antioxidant superoxide dismutase, glutathione (GSH) peroxidase, catalase, reduced GSH and glutathione-S-transferase activities and increased lipid peroxidase (LPO) activity in different organs such as heart, liver, kidney and lungs. The histological changes following the antivenom treatment were also evaluated in all these organs. There were significant alterations in the histology. Triterpenoid from methanol extract of L aspera Linn. at a dose level of 75 mg per mouse significantly attenuated (neutralized) the venom-induced antioxidant status and also the LPO activity in different organs.

Titel:	Antivenom activity of triterpenoid (C34H68O2) from Leucas aspera Linn. against Naja naja naja venom induced toxicity: Antioxidant and histological study in mice
Autor/in / Beteiligte Person:	VENKATESAN, C ; SARATHI, M ; VIMAL, S ; NAMBI, K. S. N ; SAHUL HAMEED, A. S ; BALASUBRAMANIAN, G ; THOMAS, John ; BALACHANDER, V ; SARATH BABU, V ; MOHAMMED YUSUF BILAL, S ; ABDUL MAJEED, S ; MADAN, N ; SUNDAR RAJ, N
Link:	Full Text Finder (Volltext) View record from PASCAL Archive
Zeitschrift:	Human & experimental toxicology, Jg. 33 (2014), Heft 4, S. 336-359
Veröffentlichung:	London: Sage Publications, 2014
Medientyp:	academicJournal
Umfang:	print, 86 ref
ISSN:	0960-3271 (print)
Schlagwort:	Toxicology Toxicologie Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Toxicologie des poisons d'origine animale. Antivenins Animal poisons toxicology. Antivenoms Enzyme Enzima Mammalia Ophidia Reptilia Rodentia Transferases Vertebrata Activité biologique Biological activity Actividad biológica Animal Antioxydant Antioxidant Antioxidante Antivenin Antivenom Antiveneno Glutathione transferase Histologie Histology Histología Immunsérum Antiserum Inmunosuero Naja naja Origine animale Animal origin Origen animal Origine végétale Plant origin Origen vegetal Souris Mouse Ratón Terpénoïde Terpenoid Terpenoide Toxicité Toxicity Toxicidad Triterpène Triterpene Triterpeno Venin Venom Veneno CAT GSH-PX GSH GST LPO Leucas aspera Linn Naja naja naja SOD antiserum cobra mice
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Aquaculture Biotechnology Division, OIE Reference Laboratory for WTD, Department of Zoology, C. Abdul Hakeem College, Melvisharam, Vellore District, Tamil Nadu, India ; Biotechnology Research Institute and School of Medicine, University Malaysia Sabah, Malaysia ; Department of Biology, Lakehead University, Thunder Bay, ON, Canada ; Department of Zoology, Arignar Anna Government Arts College, Cheiyar, Tamil Nadu, India ; Human Genetic Laboratory, Department of Zoology, Bharathiyar University, Coimbatore, Tamil Nadu, India ; Raja Muthiah Medical College, Chidambaram, Tamil Nadu, India Rights: Copyright 2015 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Toxicology

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