Relationship between cytomegalovirus (CMV) reactivation, CMV-driven immunity, overall immune recovery and graft-versus-leukaemia effect in children
In: British journal of haematology, Jg. 166 (2014), Heft 2, S. 229-239
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Zugriff:
The interplay between immune recovery, cytomegalovirus (CMV)-reactivation, CMV-driven immunity and graft-versus-leukaemia effect (GVL) was analysed in 108 children (median age: 8 years) who underwent haematopoietic-stem cell transplantation (HSCT) for acute leukaemia. Follow-up was 2 years unless death or relapse occurred. CMV-polymerase chain reaction (PCR) was programmed weekly until month +3 post-HSCT. Immunomonitoring consisted of sequential lymphocyte subset enumerations and analyses of T-cell proliferative and γ-interferon responses to CMV and to adenovirus. In the 108 recipients, the 2-year relapse rate (RR) was 25% (median time to onset 4·5 months; range: 24 d-17 months). CMV reactivation occurrence was 31% (median time to onset 26 d). Donor/recipient CMV serostatus did not influence RR. Among the 89 recipients disease-free after day +120, i) early CMV-reactivation before day +30 was more frequent (P = 0·01) in the relapse recipient group opposed to the non-relapse group. ii) CD8+/CD28- and CD4+CD45RA- T-cell expansions induced by CMV did not influence RR, iii) Recovery of anti-CMV and also anti-adenovirus immunity and of naive CD4+ T-cells was faster in the non-relapse group (P = 0·008; 0·009 and 0·002 respectively). In contrast to adult acute myeloid leukaemia, CMV reactivation was associated with increased RR in this paediatric series. Accelerated overall immune recovery rather than CMV-driven immunity had a favourable impact on RR.
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Relationship between cytomegalovirus (CMV) reactivation, CMV-driven immunity, overall immune recovery and graft-versus-leukaemia effect in children
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Autor/in / Beteiligte Person: | JELJELI, Mohamed ; KHOUROUJ, Valérie Guérin-El ; BARUCHEL, Andre ; DALLE, Jean-Hugues ; STERKERS, Ghislaine ; PORCHER, Raphael ; FAHD, Mony ; LEVEILLE, Sandrine ; YAKOUBEN, Karima ; OUACHEE-CHARDIN, Marie ; LEGOFF, Jerome ; CORDEIRO, Debora Jorge ; PEDRON, Beatrice |
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Zeitschrift: | British journal of haematology, Jg. 166 (2014), Heft 2, S. 229-239 |
Veröffentlichung: | Oxford: Blackwell, 2014 |
Medientyp: | academicJournal |
Umfang: | print, 1 p.1/4 |
ISSN: | 0007-1048 (print) |
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