Development and evaluation of lipid nanocarriers for quercetin delivery: A comparative study of solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), and lipid nanoemulsions (LNE)

ADITYA, N. P ; MACEDO, Ana Sofia ; et al.

In: Lebensmittel - Wissenschaft + Technologie, Jg. 59 (2014), Heft 1, S. 115-121

academicJournal - print, 3/4 p

To understand the effect of the physical state and composition of the lipid materials on the formation and performance of lipid nanocarriers, three types of carriers namely, solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and lipid nanoemulsions (LNE) were prepared and compared. Quercetin was used as a model nutraceutical compound to evaluate the potency of these nanocarriers to increase bioaccessibility. Among the developed nanocarriers, quercetin loaded and free NLC showed the smallest particle size (-34 and 47 nm) compared to SLN (~103 and 127 nm) and LNE (~82 and 83 nm). Encapsulation efficiency of quercetin in these nanocarriers was >90%. Stability of these nanocarriers in simulated stomach conditions was proved by their unaffected size and size distribution after incubation in simulated gastric fluid. Maximum bioaccessibility was observed with NLC and LNE (~60%) compared to SLN (~35%) and free quercetin solution (~7%). Controlled release was observed in enzyme free simulated intestinal fluid with maximum release being obtained with LNE compared to SLN and NLC. This study showed that by optimally controlling the lipid physical state and composition, it is possible to fabricate the lipid nanocarriers with desired properties.

Titel:	Development and evaluation of lipid nanocarriers for quercetin delivery: A comparative study of solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), and lipid nanoemulsions (LNE)
Autor/in / Beteiligte Person:	ADITYA, N. P ; MACEDO, Ana Sofia ; DOKTOROVOVA, Slavomira ; SOUTO, Eliana B ; SAEHOON, KIM ; CHANG, Pahn-Shick ; SANGHOON, KO
Link:	E-Journal im Bestand der UB Hagen? View record from PASCAL Archive
Zeitschrift:	Lebensmittel - Wissenschaft + Technologie, Jg. 59 (2014), Heft 1, S. 115-121
Veröffentlichung:	Kidlington: Elsevier, 2014
Medientyp:	academicJournal
Umfang:	print, 3/4 p
ISSN:	0023-6438 (print)
Schlagwort:	Food science technology Sciences technologies alimentaires Sciences biologiques et medicales Biological and medical sciences Sciences biologiques fondamentales et appliquees. Psychologie Fundamental and applied biological sciences. Psychology Industries agroalimentaires Food industries Appareil digestif Digestive system Aparato digestivo Polyphénol Polyphenol Polifenol Développement Development Desarrollo Etude comparative Comparative study Estudio comparativo Evaluation Evaluación Flavonoïde Flavonoid Flavonoide Intestin Gut Intestino Lipide Lipids Lípido Nanoparticule Nanoparticle Nanopartícula Nanostructure Nanoestructura Quercétine Quercetin Quercetina Solide Solid Sólido Flavonol dérivé Bioaccessibility Lipid composition Lipid nanocarrier Lipid physical state Simulated gastro intestinal fluid
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Department of Food Science and Technology, Sejong University, 98 Gunja-dong, Gwangjin-gu, Seoul 143-747, Korea, Republic of ; Faculty of Health Sciences, Fernando Pessoa University. Rua Carlos da Maia, 296, 4200-150 Porto, Portugal ; Institute of Biotechnology and Bioengineering, Centre of Genetics and Biotechnology, University of Trás-os-Montes and Alto Douro (IBBICGB-UTAD), P.O. Box 1013, 5000-801 Vila Real, Portugal ; Department of Agricultural Biotechnology, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea, Republic of Rights: Copyright 2015 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Agrifood industries

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