Association of genetic predisposition to obesity with type 2 diabetes risk in Han Chinese individuals
In: Diabetologia (Berlin), Jg. 57 (2014), Heft 9, S. 1830-1833
Online
academicJournal
- print, 7 ref
Zugriff:
Aims/hypothesis Obesity is a major risk factor for type 2 diabetes, but little is known about the contribution of BMI-associated loci to type 2 diabetes risk in East Asian populations. Methods In this study, 30 known BMI-associated variants and a genetic risk score (GRS) calculated by summing the BMI-increasing alleles of these variants were tested for associations with type 2 diabetes and related glycaemic traits in 1,873 cases of type 2 diabetes and 1,839 controls in Han Chinese individuals. Logistic and linear regression analyses were performed to detennine the association with type 2 diabetes risk or related glycaemic traits, respectively, under an additive model with or without adjustment for BMI. Results The GRS was significantly associated with increased BMI (β [SE] 0.070 [0.016]; p=1.33×10―5) in the overall population. Each additional BMI-increasing allele in the GRS increased type 2 diabetes risk by 1.029-fold (95% CI 1.008, 1.050; p=0.0056) without adjustment for BMI, and the association was slightly attenuated after adjustment for BMI (OR 1.022; 95% CI 1.002, 1.043; p=0.035). In non-diabetic controls, the GRS was also associated with HOMA of beta cell function (HOMA-B) with adjustment for BMI (β [SE] -0.876 [0.345]; p=0.011). Notably, the association of GRS with type 2 diabetes was abolished after adjusting for HOMA-B (OR 1.012; 95% CI 0.986, 1.039; p=0.380). Conclusions/interpretation Our results suggested that genetic predisposition to obesity leads to increased risk of type 2 diabetes, independent of BMI and partly through impaired beta cell function.
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Association of genetic predisposition to obesity with type 2 diabetes risk in Han Chinese individuals
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Autor/in / Beteiligte Person: | JINGWEN, ZHU ; GENG, ZONG ; XU, LIN ; LING, LU ; WEI, GAN ; LINONG, JI ; RENMING, HU ; XINGWANG, YE ; LIANG, SUN ; LOOS, Ruth J. F ; HUAIXING, LI |
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Zeitschrift: | Diabetologia (Berlin), Jg. 57 (2014), Heft 9, S. 1830-1833 |
Veröffentlichung: | Heidelberg: Springer, 2014 |
Medientyp: | academicJournal |
Umfang: | print, 7 ref |
ISSN: | 0012-186X (print) |
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