An integrated use of multiple biomarkers to investigate the individual and combined effect of copper and cadmium on the marine green mussel (Perna viridis)

GOSWAMI, Prasun ; HARIHARAN, G ; et al.

In: Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, Jg. 49 (2014), Heft 13-14, S. 1564-1577

academicJournal - print, 95 ref

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The present study documents individual and combined sub-lethal effect of one redox active (copper) and one non-redox active (cadmium) metal on green mussel (Perna viridis). The mussels were exposed to 60 μg L-1 of Cu and 150 μg L-1 of Cd (individually and in combination) for 21 days. Histopathological and ultrastructural studies revealed significant metal induced alterations such as vacuolization, fusion of gill lamellae, enhance mucous deposition, hyperplasia and necrosis in gills. Antioxidant enzyme assays revealed significant increase in superoxide dismutase (SOD), glutathione S-transferase (GST) and glutathione peroxidase (GPx) activity. Similarly, single exposure to Cd and Cu caused significant induction in Malate dehydrogenase (MDH) activity. However, combined Cu+Cd exposure modulated suppression in MDH activity. Unlike MDH, Cu and Cd individual exposure resulted in a decrease in esterase (EST) activity, but their combined exposure caused an induction. Non-enzymatic biomarkers such as lipid peroxidation (LPO) and metallothionein (MT) levels showed no significant change in response to Cu exposure, whereas, individual Cd exposure or Cd exposure in combination with Cu caused significant changes in their levels. Comet assay revealed a significant increase in DNA damage upon metal exposure. These results indicate that Cu (redox active) and Cd (non-redox active) can induce measurable physiological, biochemical as well as genotoxic perturbations in mussels even at sub-lethal concentrations. A monitoring programme based on the biomarkers discussed here would be useful to study the effect of metal pollutants reaching the coastal waters.

Titel:	An integrated use of multiple biomarkers to investigate the individual and combined effect of copper and cadmium on the marine green mussel (Perna viridis)
Autor/in / Beteiligte Person:	GOSWAMI, Prasun ; HARIHARAN, G ; GODHANTARAMAN, Nallamuthu ; MUNUSWAMY, Natesan
Link:	View record from PASCAL Archive
Zeitschrift:	Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, Jg. 49 (2014), Heft 13-14, S. 1564-1577
Veröffentlichung:	Philadelphia, PA: Taylor & Francis, 2014
Medientyp:	academicJournal
Umfang:	print, 95 ref
ISSN:	1093-4529 (print)
Schlagwort:	Ecology Ecologie Environment Environnement Pollution Sciences biologiques et medicales Biological and medical sciences Sciences biologiques fondamentales et appliquees. Psychologie Fundamental and applied biological sciences. Psychology Ecologie animale, vegetale et microbienne Animal, plant and microbial ecology Ecologie appliquée Applied ecology Ecotoxicologie, effets biologiques de la pollution Ecotoxicology, biological effects of pollution Action de la pollution et effets secondaires des pesticides sur les protozoaires et les invertébrés Effects of pollution and side effects of pesticides on protozoa and invertebrates Bivalvia Elément trace Trace element Elemento traza Invertebrata Mollusca Métal lourd Heavy metal Metal pesado Métal transition Transition metal Metal transición Toxicité Toxicity Toxicidad Activité enzymatique Enzymatic activity Actividad enzimática Antioxydant Antioxidant Antioxidante Association toxique Toxic association Asociación toxíca Branchie Gill Branquia Cadmium Cadmio Cuivre Copper Cobre DNA Dose sublétale Sublethal dose Dosis subletal Génotoxicité Genotoxicity Genotoxicidad Histologie Histology Histología Histopathologie Histopathology Histopatología Interaction toxique Poison interaction Interacción tóxica Lipide Lipids Lípido Marqueur biologique Biological marker Marcador biológico Microscopie électronique balayage Scanning electron microscopy Microscopía electrónica barrido Milieu marin Marine environment Medio marino Morphologie Morphology Morfología Perna viridis Peroxydation Peroxidation Peroxidación Polluant Pollutant Contaminante Stress oxydatif Oxidative stress Estrés oxidativo Structure surface Surface structure Estructura superficie Test génotoxicité Genotoxity test Prueba genotoxicidad Ultrastructure Ultraestructura Antioxidant enzymes DNA damage biomarker genotoxicity histology metal-metal interaction sub-lethal toxicity ultrastructure
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Unit of Aquaculture and Cryobiology, Department of Zoology, University of Madras, Chennai, India ; Institute of Ocean Management, Anna University, Chennai, India ; UGC Academic Staff College, University of Madras, Chennai, India Rights: Copyright 2015 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Animal, vegetal and microbial ecology

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