Increased c-fos expression in spinal neurons induced by electrical stimulation of the ureter in the rat
In: Brain research, Jg. 709 (1996), Heft 2, S. 197-204
academicJournal
- print, 33 ref
Zugriff:
The spinal processing of afferent input from the ureter was examined using an immunocytochemical technique to detect the expression of c-fos, an immediate early gene. Proximal and distal sites in one ureter were electrically stimulated separately or together at intensities that elicited a pseudo-affective response (an increase in arterial pressure). Very few Fos + cells (range : 0.6-6.6 cells/half section were present in the L1-L2, L5-52 spinal segments in sham operated control animals ; however, following stimulation of the ureter, a significant increase in the numbers of Fos + cells was detected at spinal levels L1-L2 (mean 24.5-33.1 cells/half section) and L6-S1 (mean 17.4-33.0 cells/half section). In L6-S1, the numbers of Fos + cells were significantly greater ipsilateral (mean 25.2 cells/half section) vs. contralateral (12.3 cells/half section) to stimulation ; whereas in L1-L2, the numbers were similar on both sides of the spinal cord. In L1-L2, a greater percentage of Fos + cells was present in superficial medial (MDH, 49.7%) and lateral dorsal horn (LDH, 40.8%) ; whereas in L6-S1, the cells were more numerous in sacral parasympathetic nucleus (SPN, 38.7%) and LDH (25.6%) regions. This distribution of Fos + cells varies in a number of respects from that noted in previous experiments after chemical irritation of the urinary bladder and urethra which activated neurons only in L6-S1 and primarily in the DCM and MDH. The results indicate that nociceptive afferent inputs from different areas of the urinary tract are processed in different regions of the spinal cord.
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Increased c-fos expression in spinal neurons induced by electrical stimulation of the ureter in the rat
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Autor/in / Beteiligte Person: | MATSUMOTO, G ; VIZZARD, M. A ; HISAMITSU, T ; DE GROAT, W. C |
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Zeitschrift: | Brain research, Jg. 709 (1996), Heft 2, S. 197-204 |
Veröffentlichung: | Amsterdam; London; New York, NY: Elsevier, 1996 |
Medientyp: | academicJournal |
Umfang: | print, 33 ref |
ISSN: | 0006-8993 (print) |
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