Accumulation of 99Tcm-polyclonal immunoglobulin in different stages of infection : An experimental study
In: Nuclear medicine communications, Jg. 17 (1996), Heft 5, S. 430-434
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Zugriff:
In this experimental study, the utility of 99Tcm-polyclonal human immunoglobulin (99Tcm-HIG) for localizing acute and chronic phases of inflammatory lesions was investigated. Three groups of rats were inoculated with Staphylococcus aureus in the right thigh. Then, 24 h (group I, n = 12), 48 h (group II, n = 12) and 72 h (group III, n = 12) post-inoculation, the rats received 40 MBq 99Tcm-HIG into the jugular vein. In addition, two control rats were studied at 24 h after inoculation of sterile saline. Both visual and quantitative evaluations were undertaken. The acute and chronic stages of inflammation were determined by pathological examination. The mean (±S.D.) lesion/contralateral uptake ratios at 4 and 24 h after 99Tcm-HIG injection were: group I, 1.22 ± 0.1 and 2.12 ± 0.16; group II, 1.15 ± 0.08 and 2.25 ± 0.16; group III, 1.06 ± 0.09 and 2.08 ± 0.14. In conclusion, the acute and chronic phases of infection showed non-significant differences in 99Tcm-HIG uptake ratios.
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Accumulation of 99Tcm-polyclonal immunoglobulin in different stages of infection : An experimental study
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Autor/in / Beteiligte Person: | BURAK, Z ; ÖZCAN, Z. B ; ÖZCAN, C ; ÖZACAR, T ; BASDEMIR, G ; ERDEM, S ; ARGON, M ; ERDENER, A ; DUMAN, Y |
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Zeitschrift: | Nuclear medicine communications, Jg. 17 (1996), Heft 5, S. 430-434 |
Veröffentlichung: | Hagerstown, MD: Lippincott Williams & Wilkins, 1996 |
Medientyp: | academicJournal |
Umfang: | print, 30 ref |
ISSN: | 0143-3636 (print) |
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