Postnatal methylazoxymethanol : sensitive periods and regional selectivity of effects
In: Neurotoxicology and teratology, Jg. 16 (1994), Heft 6, S. 631-637
academicJournal
- print, 44 ref
Zugriff:
Work on neonatal MAM exposure has focused primarily on exposure within the first week postpartum, and on resulting hypoplasia or stunting of the cerebellum. Rats in this study were exposed to MAM on 4 consecutive postnatal days (PND), beginning at one of six ages, from birth through weaning (PND 1, 5, 9, 13, 17, or 21). MAM was administered subcutaneously in doses of 3, 4, or 5 mg/kg twice per day. Rats were sacrificed at PNDs 28 or 84. The most sensitive age for MAM-induced stunting was determined to be PNDs 1-4. When 5 mg/kg MAM was administered twice daily on PNDs 1-4, body weight was reduced by 24% at age 28 days.
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Postnatal methylazoxymethanol : sensitive periods and regional selectivity of effects
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Autor/in / Beteiligte Person: | SULLIVAN-JONES, P ; ALI, S. F ; GOUGH, B ; HOLSON, R. R |
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Zeitschrift: | Neurotoxicology and teratology, Jg. 16 (1994), Heft 6, S. 631-637 |
Veröffentlichung: | New York, NY: Elsevier Science, 1994 |
Medientyp: | academicJournal |
Umfang: | print, 44 ref |
ISSN: | 0892-0362 (print) |
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