Functional analysis of interactions between tat and the trans-activation response element of human immunodeficiency virus type 1 in cells
In: Journal of virology, Jg. 67 (1993), Heft 9, S. 5617-5622
Online
academicJournal
- print, 33 ref
Zugriff:
Transcriptional trans-activation of the human immunodeficiency virus type 1 long terminal repeat requires that the virally encoded Tat effector interacts with its target trans-activation response element (TAR) RNA stem-loop. Although the arginine-rich region of Tat from amino acids 49 to 59 is sufficient to bind to TAR RNA in vitro, the RNA-binding domain of Tat has not been defined in vivo. Human immunodeficiency virus type 1 also encodes the Rev protein, which acts through an RNA stem-loop called the Rev-response element to transport unspliced and singly spliced viral RNA species from the nucleus to the cytoplasm.
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Functional analysis of interactions between tat and the trans-activation response element of human immunodeficiency virus type 1 in cells
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Autor/in / Beteiligte Person: | YING, LUO ; MADORE, S. J ; PARSLOW, T. G ; CULLEN, B. R ; PETERLIN, B. M |
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Zeitschrift: | Journal of virology, Jg. 67 (1993), Heft 9, S. 5617-5622 |
Veröffentlichung: | Washington, DC: American Society for Microbiology, 1993 |
Medientyp: | academicJournal |
Umfang: | print, 33 ref |
ISSN: | 0022-538X (print) |
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