Growth factor-induced process formation of megakaryocytes derived from CFU-MK
In: British journal of haematology, Jg. 85 (1993), Heft 2, S. 260-269
academicJournal
- print, 1 p
Zugriff:
The extended cytoplasmic processes from megakaryocytes (MK) are believed to be structural intermediates between MK and platelets. We could observe differentiation of purified rat CFU-MK toward mature MK to form extended cytoplasmic processes. Recombinant rat interleukin-3 (IL-3), human erythropoietin (Epo), and human interleukin-6 (IL-6) each was able to stimulate process formation although they varied somewhat in their potential. Electron microscopic observations showed that these processes were very similar to those from mature MK so far reported. The combination of IL-6 with IL-3 or Epo synergistically increased the number of MK forming processes without further increase in tnumber of total MK formed in the presence of IL-3 or Epo alone.
Titel: |
Growth factor-induced process formation of megakaryocytes derived from CFU-MK
|
---|---|
Autor/in / Beteiligte Person: | INOUE, H ; ISHII, H ; TSUTSUMI, M ; TAKAHASHI, N ; SATO, M ; SHIMADA, Y ; KATO, T ; SUDO, T ; MIYAZAKI, H |
Link: | |
Zeitschrift: | British journal of haematology, Jg. 85 (1993), Heft 2, S. 260-269 |
Veröffentlichung: | Oxford: Blackwell, 1993 |
Medientyp: | academicJournal |
Umfang: | print, 1 p |
ISSN: | 0007-1048 (print) |
Schlagwort: |
|
Sonstiges: |
|