Regulatory elements involved in tax-mediated transactivation of the HTLV-I LTR
In: Virology (New York, NY), Jg. 196 (1993), Heft 2, S. 442-450
academicJournal
- print, 1 p. 1/2
Zugriff:
HTLV-I is the etiologic agent of adult T-cell leukemia. In this study, we investigated the regulatory elements and cellular transcription factors which function in modulating HTLV-I gene expression in response to the viral transactivator protein, tax. Transfection experiments into Jurkat cells of a variety of site-directed mutants in the HTLV-I LTR indicated that each of the three motifs A, B, and C within the 21-bp repeats, the binding sites for the Ets family of proteins, and the TATA box all influenced the degree of tax-mediated activation. Tax is also able to activate gene expression of other viral and cellular promoters. Tax activation of the IL-2 receptor and the HIV-I LTR is mediated through NF-κB motifs.
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Regulatory elements involved in tax-mediated transactivation of the HTLV-I LTR
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Autor/in / Beteiligte Person: | SEELER, J.-S ; MUCHARDT, C ; PODAR, M ; GAYNOR, R. B |
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Zeitschrift: | Virology (New York, NY), Jg. 196 (1993), Heft 2, S. 442-450 |
Veröffentlichung: | San Diego, CA: Elsevier, 1993 |
Medientyp: | academicJournal |
Umfang: | print, 1 p. 1/2 |
ISSN: | 0042-6822 (print) |
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