Cytokine-induced C-type natriuretic peptide (CNP) secretion from vascular endothelial cells : evidence for CNP as a novel autocrine/paracrine regulator from endothelial cells
In: Endocrinology (Philadelphia), Jg. 133 (1993), Heft 6, S. 3038-3041
Online
academicJournal
- print, 29 ref
Zugriff:
We previously demonstrated that C-type natriuretic peptide (CNP), originally isolated from the porcine brain, is produced by endothelial cells and proposed that CNP can exert local control over vascular tone and growth as a local regulator from endothelial cells. Since cytokines play pivotal roles in the control of vascular tone and structure, we have examined effects of various cytokines on CNP secretion from endothelial cells using the specific radioimmunoassay for CNP. While interleukin (IL)-2 had no significant effect on CNP secretion, IL-1α, IL-1β and tumor necrosis factor (TNF)-α stimulated CNP secretion in a time- and dose-dependent manner.
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Cytokine-induced C-type natriuretic peptide (CNP) secretion from vascular endothelial cells : evidence for CNP as a novel autocrine/paracrine regulator from endothelial cells
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Autor/in / Beteiligte Person: | SUGA, S.-I ; ITOH, H ; KOMATSU, Y ; OGAWA, Y ; HAMA, N ; YOSHIMASA, T ; NAKAO, K |
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Zeitschrift: | Endocrinology (Philadelphia), Jg. 133 (1993), Heft 6, S. 3038-3041 |
Veröffentlichung: | Bethesda, MD: Endocrine Society, 1993 |
Medientyp: | academicJournal |
Umfang: | print, 29 ref |
ISSN: | 0013-7227 (print) |
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