Oncogene activation of HIV-LTR-driven expression via the NF-χB binding sites
In: Nucleic acids research, Jg. 21 (1993), Heft 22, S. 5229-5234
Online
academicJournal
- print, 44 ref
Zugriff:
The Raf-1 proto-oncogene product is a highly regulated serine/threonine kinase that functions in signal transduction downstream from growth factor receptors and upstream from nuclear proto-oncogene products. Using a transient cotransfection assay we have found that activated Raf-1 activates expression from the HIV-LTR. Analysis of a series of 5' deletion and point mutations revealed the NF-κB motifs as the Raf-responsive element in the HIV-LTR. Moreover, Raf-BXB activated expression from heterologous promoters driven by the HIV NF-κB binding sites. In addition to Raf, we show that v-Src, v-H-Ras and v-Mos activate HIV-LTR expression through the NF-κB binding sites and v-H-Ras-induced HIV-LTR expression is mediated by Raf-1.
| Titel: |
Oncogene activation of HIV-LTR-driven expression via the NF-χB binding sites
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| Autor/in / Beteiligte Person: | BRUDER, J. T ; HEIDECKER, G ; TSE-HUA, TAN ; WESKE, J. C ; DERSE, D ; RAPP, U. R |
| Link: | |
| Zeitschrift: | Nucleic acids research, Jg. 21 (1993), Heft 22, S. 5229-5234 |
| Veröffentlichung: | Oxford: Oxford University Press, 1993 |
| Medientyp: | academicJournal |
| Umfang: | print, 44 ref |
| ISSN: | 0305-1048 (print) |
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