Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product
In: The Journal of biological chemistry (Print), Jg. 269 (1994), Heft 1, S. 62-65
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academicJournal
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Zugriff:
The dbl oncogene product contains a 238-amino acid domain, which is shared by an expanding family of growth regulatory proteins. These include the Saccharomyces cerevisiae cell division cycle protein, CDC24, the breakpoint cluster region protein, the ect2 and vav oncogene products, and the brain GDP-releasing factor for Ras. Previous studies have provided evidence that oncogenic Dbl or an associated protein stimulates GDP dissociation from the human species (Hs) homolog of CDC42. We show here that Dbl specifically complexes with the GDP-bound forms of CDC42Hs and RhoA, but not Rac1 or TC10, and that this specificity correlates with the ability of Dbl to act as a GDP-releasing factor.
| Titel: |
Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product
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| Autor/in / Beteiligte Person: | HART, M. J ; EVA, A ; ZANGRILLI, D ; AARONSON, S. A ; EVANS, T ; CERIONE, R. A ; YI, ZHENG |
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| Zeitschrift: | The Journal of biological chemistry (Print), Jg. 269 (1994), Heft 1, S. 62-65 |
| Veröffentlichung: | Bethesda, MD: American Society for Biochemistry and Molecular Biology, 1994 |
| Medientyp: | academicJournal |
| Umfang: | print, 28 ref |
| ISSN: | 0021-9258 (print) |
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