Immunohistochemical detection of mutant p53 protein in epithelial ovarian cancer using polyclonal antibody CMI : correlation with histopathology and clinical features
In: British journal of cancer, Jg. 69 (1994), Heft 3, S. 609-612
Online
academicJournal
- print, 15 ref
Zugriff:
Approximately 30-50% of cases of ovarian adenocarcinoma harbour mutations in the p53 tumour-suppressor gene associated with elevated levels of the protein detected by immunohistochemical staining. To investigate any relation between the presence of mutant p53 and clinicopathological features of disease, we examined a series of 50 cases of epithelial ovarian adenocarcinoma for expression of p53 by immunohistological staining on fixed, paraffin-embedded tissue sections using the polyclonal antibody CM1, and by direct nucleotide sequencing of polymerase chain reaction-amplified DNA from selected cases.
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Immunohistochemical detection of mutant p53 protein in epithelial ovarian cancer using polyclonal antibody CMI : correlation with histopathology and clinical features
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Autor/in / Beteiligte Person: | RENNINSON, J ; BAKER, B. W ; MCGOWN, A. T ; MURPHY, D ; NORTON, J. D ; FOX, B. W ; CROWTHER, D |
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Zeitschrift: | British journal of cancer, Jg. 69 (1994), Heft 3, S. 609-612 |
Veröffentlichung: | Basingstoke: Nature Publishing Group, 1994 |
Medientyp: | academicJournal |
Umfang: | print, 15 ref |
ISSN: | 0007-0920 (print) |
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