TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12
In: Human molecular genetics (Print), Jg. 3 (1994), Heft 6, S. 897-901
Online
academicJournal
- print, 35 ref
Zugriff:
A gene for a novel, putative cytoplasmic tyrosine kinase, TXK has been isolated from a human peripheral blood cDNA library. The complete nucleotide sequence of the cDNA indicates that it is related most closely to EMT, a tyrosine kinase of T cells and to the B-cell tyrosine kinase Btk, which is mutated in X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency disease (XID) in mouse. TXK, like BTK, is a member of the Tec sub-family of Src-type (non-receptor) tyrosine kinases. Like similar Tec subfamily members, and unlike the other Src kinases, TXK lacks both the N-terminal myristylation signal and the C-terminal regulatory tyrosine. TXK expression is detected primarily in T cells and some myeloid cell lines but not in a number of other cell types.
| Titel: |
TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12
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| Autor/in / Beteiligte Person: | HAIRE, R. N ; OHTA, Y ; LEWIS, J. E ; SHU MAN, FU ; KROISEL, P ; LITMAN, G. W |
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| Zeitschrift: | Human molecular genetics (Print), Jg. 3 (1994), Heft 6, S. 897-901 |
| Veröffentlichung: | Oxford: Oxford University Press, 1994 |
| Medientyp: | academicJournal |
| Umfang: | print, 35 ref |
| ISSN: | 0964-6906 (print) |
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