Differences in immune recognition of cytochrome P4502D6 by kiver kidney microsomal (LKM) antibody in autoimmune hepatitis and chronic hepatitis C virus infection
In: Clinical and experimental immunology (Print), Jg. 97 (1994), Heft 1, S. 94-99
Online
academicJournal
- print, 24 ref
Zugriff:
LKM-1 antibody, which characterizes a subtype of autoimmune hepatitis (AIH), is also found in some patients with chronic hepatitis C virus (HCV) infection. It has been suggested that HCV initiates autoimmunity through molecular mimicry, because there is partial identity between HCV and cytochrome P4502D6 (CYP2D6), the putative target of LKM-1. Whether CYP2D6 is the target of LKM-1 in HCV-related liver disease, however, is controversial. To clarify this issue, we have studied by phage plaque assay and Western blot the reactivity to recombinant CYP2D6, isolated from a human liver cDNA library, in 55 patients with LKM-1, 18 (14 females, median age 12 years) anti-HCV-negative, with classical AIH, and 37 (21 females, median age 52 years) anti-HCV-positive.
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Differences in immune recognition of cytochrome P4502D6 by kiver kidney microsomal (LKM) antibody in autoimmune hepatitis and chronic hepatitis C virus infection
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Autor/in / Beteiligte Person: | MA, Y ; PEAKMAN, M ; LOBO-YEO, A ; WEN, L ; LENZI, M ; GAKEN, J ; FARZANEH, F ; MIELI-VERGANI, G ; BIANCHI, F. B ; VERGANI, D |
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Zeitschrift: | Clinical and experimental immunology (Print), Jg. 97 (1994), Heft 1, S. 94-99 |
Veröffentlichung: | Oxford: Blackwell, 1994 |
Medientyp: | academicJournal |
Umfang: | print, 24 ref |
ISSN: | 0009-9104 (print) |
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