Polarized secretion of β-amyloid precursor protein and amyloid β-peptide in MDCK cells
In: Proceedings of the National Academy of Sciences of the United States of America, Jg. 91 (1994), Heft 4, S. 1564-1568
Online
academicJournal
- print, 47 ref
Zugriff:
The β-amyloid precursor protein (βAPP) is a widely expressed integral membrane protein that is proteolytically processed to yield several secreted derivatives, including soluble APP (APPs), the 4-kDa amyloid C-peptide (AC), and a related 3-kDa peptide (p3). To understand βAPP trafficking and processing, we analyzed the sorting of βAPP in Madin-Darby canine kidney (MDCK) cells, an epithelial cell known to possess physiologically distinct apical and basolateral plasma membranes. Processing of βAPP resulted in highly polarized secretion of APps.
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Polarized secretion of β-amyloid precursor protein and amyloid β-peptide in MDCK cells
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Autor/in / Beteiligte Person: | HAASS, C ; KOO, E. H ; TEPLOW, D. B ; SELKOE, D. J |
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Zeitschrift: | Proceedings of the National Academy of Sciences of the United States of America, Jg. 91 (1994), Heft 4, S. 1564-1568 |
Veröffentlichung: | Washington, DC: National Academy of Sciences of the United States of America, 1994 |
Medientyp: | academicJournal |
Umfang: | print, 47 ref |
ISSN: | 0027-8424 (print) |
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