Surface-associated filamentous hemagglutinin induces autoagglutination of Bordetella pertussis
In: Infection and immunity, Jg. 62 (1994), Heft 10, S. 4261-4269
Online
academicJournal
- print, 48 ref
Zugriff:
Filamentous hemagglutinin (FHA) is a major adhesin produced by Bordetellapertussis, the etiologic agent of whooping cough. FHA has been shown to be surface associated but is also secreted by virulent bacteria. Microscopic observations of lungs of mice infected with B. pertussis showed that the bacteria grow as clusters within the alveolar lumen. When B. pertussis was cultivated in vitro with chemically defined medium, bacteria grew as aggregates, mimicking growth observed in vivo. This aggregation was abolished by the addition of cyclodextrin (CDX) to the growth medium and depended on the production of FHA, because a mutant lacing the FHA structural gene failed to form aggregates in a CDX-free medium.
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Surface-associated filamentous hemagglutinin induces autoagglutination of Bordetella pertussis
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Autor/in / Beteiligte Person: | MENOZZI, F. D ; BOUCHER, P. E ; RIVEAU, G ; GANTIEZ, C ; LOCHT, C |
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Zeitschrift: | Infection and immunity, Jg. 62 (1994), Heft 10, S. 4261-4269 |
Veröffentlichung: | Washington, DC: American Society for Microbiology, 1994 |
Medientyp: | academicJournal |
Umfang: | print, 48 ref |
ISSN: | 0019-9567 (print) |
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