Postnatal changes in the quantities of globin chains and hemoglobin types in two babies with HbH disease
In: American journal of hematology, Jg. 42 (1993), Heft 1, S. 86-90
Online
academicJournal
- print, 18 ref
Zugriff:
We have studied two babies with Hb H disease from birth to about six months of age and analyzed the changes in the relative quantities of the five globin chains (ζ, α, β, Gγ, Aγ) and the four hemoglobins (Hb F, Hb A, Hb Bart's, Hb H) using different high performance liquid chromatography procedures. The types of Hb H disease were -(SEA)/-α(3.7 kb) and -(Fil)/-α(3.7 kb); the larger (Fil) deletion includes the functional ζ2-globin gene, explaining the higher ζ chain level in the baby with the (SEA)/-α (3.7 kb) type.
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Postnatal changes in the quantities of globin chains and hemoglobin types in two babies with HbH disease
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Autor/in / Beteiligte Person: | MCKIE, K. M ; GU, L.-H ; GU, Y.-C ; HUISMAN, T. H. J |
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Zeitschrift: | American journal of hematology, Jg. 42 (1993), Heft 1, S. 86-90 |
Veröffentlichung: | New York, NY: Wiley-Liss, 1993 |
Medientyp: | academicJournal |
Umfang: | print, 18 ref |
ISSN: | 0361-8609 (print) |
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