Clinical importance of CD7 expression in acute myelocytic leukemia
In: Blood, Jg. 81 (1993), Heft 9, S. 2399-2405
Online
academicJournal
- print, 38 ref
Zugriff:
Forty patients (9 females and 31 males; mean age 41.9 years) with CD7+ acute myelocytic leukemia (AML) were investigated; they were classified into the following subgroups according to French-American-British classification: 15 M1, 18 M2, 3 M4, and 4 MS. Leukemic cells from all the patients were negative for T-cell-specific antigens, surface CD3, and T-cell-receptor molecules. The sex and age distributions were different from those of CD7- AML patients (P<.01). Hepatomegaly and central nervous system involvement were also frequent in the CD7+ AML patients. The phenotype of and responsiveness to hematopoietic growth factors by the leukemic cells showed their immaturity, as evidenced by frequent expression of CD34, HLA-DR, and TdT, and the greatest growth response to interleukin-3.
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Clinical importance of CD7 expression in acute myelocytic leukemia
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Autor/in / Beteiligte Person: | KITA, K ; MIWA, H ; KYO, T ; DOHY, H ; KAMADA, N ; NASU, K ; UCHINO, H ; NAKASE, K ; KAWAKAMI, K ; KOBAYASHI, T ; SHIRAKAWA, S ; TANAKA, I ; OHTA, C ; TSUTANI, H ; OGUMA, S |
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Zeitschrift: | Blood, Jg. 81 (1993), Heft 9, S. 2399-2405 |
Veröffentlichung: | Washington, DC: The Americain Society of Hematology, 1993 |
Medientyp: | academicJournal |
Umfang: | print, 38 ref |
ISSN: | 0006-4971 (print) |
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