Regulation of mouse choroid plexus apical Cl- and K+ channels by serotonin
In: Brain research, Jg. 617 (1993), Heft 2, S. 285-295
academicJournal
- print, 35 ref
Zugriff:
Using patch-clamp techniques, we have characterized ion channels in the apical membrane of the mouse choroid plexus epithelium and have examined the effect of serotonin on these channels. When the pipette contained 140 mM KCl and the bath contained NaCl Ringer solution, cell-attached patches revealed both Cl- and K+ channels. The Cl- channel was activated by hyperpolarizing membrane potentials, and 70% were also activated by large depolarizing potentials (pipette potential, Vp, more negative than -40 mV). The channel exhibited linear current-voltage (I-V) relations with a conductance of 4±1 pS (n=30), and a reversal potential at Vp=-14±1 mV (n=30). The majority of the K+ channels (84%) were activated by depolarizing membrane potentials.
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Regulation of mouse choroid plexus apical Cl- and K+ channels by serotonin
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Autor/in / Beteiligte Person: | HUNG, B. C. P ; LOO, D. D. F ; WRIGHT, E. M |
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Zeitschrift: | Brain research, Jg. 617 (1993), Heft 2, S. 285-295 |
Veröffentlichung: | Amsterdam; London; New York, NY: Elsevier, 1993 |
Medientyp: | academicJournal |
Umfang: | print, 35 ref |
ISSN: | 0006-8993 (print) |
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