Comparative effects of anthelmintics on c-MDH from Molinema dessetae (Nematoda: Filarioidea) and from a mammal
In: Parasitology research (1987), Jg. 79 (1993), Heft 5, S. 397-401
Online
academicJournal
- print, 24 ref
Zugriff:
Malate dehydrogenase (MDH) (E.C.1.1.1.37) activity was detected in the filaria Molinema dessetae at a level similar to those found in other filariae. In M. dessetae, the cytoplasmic form (c-MDH) predominated and the study was performed on partially purified fractions. The pH optimum for oxaloacetate reduction was 6.1, with maximal activity at 7811 nmol min-1 mg protein-1, but high concentrations of oxaloacetate inhibited MDH activity. The Km value for oxaloacetate was determined as 22 μM for M. dessetae c-MDH and 33 μM for mammalian c-MDH. Anthelmintic drugs were compared as potential inhibitors of filarial and mammalian c-MDH.
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Comparative effects of anthelmintics on c-MDH from Molinema dessetae (Nematoda: Filarioidea) and from a mammal
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Autor/in / Beteiligte Person: | LOISEAU, P. M ; MAAROUF, M ; GAYRAL, P ; PETEK, F |
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Zeitschrift: | Parasitology research (1987), Jg. 79 (1993), Heft 5, S. 397-401 |
Veröffentlichung: | Berlin: Springer, 1993 |
Medientyp: | academicJournal |
Umfang: | print, 24 ref |
ISSN: | 0932-0113 (print) |
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