Chromosomal mapping of genetic locus associated with thymus-size enlargement in BUF/Mna rats
In: Japanese journal of cancer research, Jg. 84 (1993), Heft 8, S. 838-840
Online
academicJournal
- print, 6 ref
Zugriff:
The thymoma-prone rat of the BUF/Mna strain is a useful model for human thymoma. In this strain thymoma development is regulated by a single autosomal susceptible gene, Tsr-1. At pre-thymoma age, BUF/Mna rats have extremely large thymuses, when compared to those of other strains of rats. Genetic studies in crosses between BUF/Mna rats with large thymuses and WKY/NCrj rats with small thymuses suggested the presence of a major autosomal gene, Ten-1, which contributes to thymus enlargement in a backcross population. Linkage studies between Ten-1 and microsatellite markers in backcross rats of (WKY/NCrj×BUF/Mna)F1×BUF/Mna have led to the localization of Ten-1 in chromosome 1. This result may provide an approach to clone Tsr-1, which could be allelic to Ten-1.
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Chromosomal mapping of genetic locus associated with thymus-size enlargement in BUF/Mna rats
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Autor/in / Beteiligte Person: | MURAKUMO, Y ; TAKAHASHI, M ; ARAKAWA, A ; SAITO, M ; AMO, H ; KATOH, H ; MATSUYAMA, M |
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Zeitschrift: | Japanese journal of cancer research, Jg. 84 (1993), Heft 8, S. 838-840 |
Veröffentlichung: | Tokyo: Japanese Cancer Association, 1993 |
Medientyp: | academicJournal |
Umfang: | print, 6 ref |
ISSN: | 0910-5050 (print) |
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