Altered vasopressin response to metochlopramide in multiple system atrophy : evidence of a cholinergic defect in the hypothalamus
In: Acta neurologica scandinavica, Jg. 85 (1992), Heft 4, S. 299-303
academicJournal
- print, 18 ref
Zugriff:
Multiple system atrophy (MSA) is a heterogeneous group of central neurological degenerations often associated with diffuse deterioration of the hypothalamic cholinergic neurons. In the hypothesis of an altered cholinergic regulation of vasopressin release, we evaluated vasopressin response to metoclopramide (20 mg i.v.), a cholinomimetic agonist, in 12 MSA patients. In the same patients the hemodynamic and osmolal control of vasopressin was also evaluated. We found that MSA patients had significantly lower basal plasma vasopressin values and higher plasma osmolality than control subjects. However, they displayed a normal vasopressin response to osmotic stimulation.
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Altered vasopressin response to metochlopramide in multiple system atrophy : evidence of a cholinergic defect in the hypothalamus
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Autor/in / Beteiligte Person: | NORBIATO, G ; BEVILACQUA, M ; RIGHINI, V ; CHEBAT, E ; VAGO, T ; BERTORA, P ; CASTELLI, L ; MANGONI, A |
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Zeitschrift: | Acta neurologica scandinavica, Jg. 85 (1992), Heft 4, S. 299-303 |
Veröffentlichung: | Oxford: Blackwell, 1992 |
Medientyp: | academicJournal |
Umfang: | print, 18 ref |
ISSN: | 0001-6314 (print) |
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