Effect of subcutaneous administration of the chemical algogen formalin, on 5-HT metabolism in the nucleus raphe magnus and the medullary dorsal horn : a voltammetric study in freely moving rats
In: Brain research, Jg. 590 (1992), Heft 1-2, S. 250-254
academicJournal
- print, 39 ref
Zugriff:
The effect of subcutaneous administration of the chemical algogen formalin, on serotonin (5-HT) metabolism in the nucleus raphe magnus (NRM) and the medullary dorsal horn (MDH) has been investigated using in vivo 5-hydroxyindole electrochemical (peak «3») detection with treated, multi-carbon fiber electrodes and differential pulse, or normal pulse, voltammetry in freely moving rats. The subcutaneous (s.c.) injection of 50 μl of 10% formalin in the left forepaw was followed, at the NRM level, by a significant increase in the voltammograms as compared to controls (50 μl of saline 0.9% s.c. in left forepaw) for about 70 min after the injection, before a return to control values.
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Effect of subcutaneous administration of the chemical algogen formalin, on 5-HT metabolism in the nucleus raphe magnus and the medullary dorsal horn : a voltammetric study in freely moving rats
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Autor/in / Beteiligte Person: | PUIG, S ; RIVOT, J. P ; BESSON, J. M |
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Zeitschrift: | Brain research, Jg. 590 (1992), Heft 1-2, S. 250-254 |
Veröffentlichung: | Amsterdam; London; New York, NY: Elsevier, 1992 |
Medientyp: | academicJournal |
Umfang: | print, 39 ref |
ISSN: | 0006-8993 (print) |
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