The MRC OX-47 antigen is a member of the immunoglobulin superfamily with an unusual transmembrane sequence
In: European journal of immunology, Jg. 21 (1991), Heft 3, S. 671-679
Online
academicJournal
- print, 42 ref
Zugriff:
The MRC OC-47 monoclonal antibody recognizes a membrane antigen present at low levels on many lymphocytes but whose expression is markedly increased on activation with mitogens. cDNA clones for the OX-47 antigen were isolated from an expression library and the protein sequence deduced. It contains a leader sequence giving a mature protein of 251 amino acids with a single putative transmembrane region, a cytoplasmic domain of 40 amino acids and an extracellular domain of 187 amino acids that contained two immunoglobulin-like domains. The putative transmembrane sequence includes a glutamic acid residue within the hydrophobic sequence.
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The MRC OX-47 antigen is a member of the immunoglobulin superfamily with an unusual transmembrane sequence
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Autor/in / Beteiligte Person: | FOSSUM, S ; MALLETT, S ; BARCLAY, A. N |
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Zeitschrift: | European journal of immunology, Jg. 21 (1991), Heft 3, S. 671-679 |
Veröffentlichung: | Weinheim: Wiley-VCH, 1991 |
Medientyp: | academicJournal |
Umfang: | print, 42 ref |
ISSN: | 0014-2980 (print) |
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