Addition of nitroalkanes to ortho-halo-nitrobenzenes: a new synthesis of 4-chloro-7-(trifluoromethyl)quinoline
In: Tetrahedron letters, Jg. 31 (1990), Heft 8, S. 1093-1096
academicJournal
- print, 7 ref
Zugriff:
Base-mediated reaction of ortho-nitroaryl chlorides and fluorides with nitroalkanes followed by an oxidative Nef reaction proves aryl ketones. With this simple procedure, methylketone 6 was prepared in 91% yield. 6 was then converted in three steps (60-65% yield) to 4-chloro-7-(trifluoromethyl) quinoline (2), an intermediate in the synthesis of the antihypertensive agent losulazine (U-54, 669, 1).
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Addition of nitroalkanes to ortho-halo-nitrobenzenes: a new synthesis of 4-chloro-7-(trifluoromethyl)quinoline
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Autor/in / Beteiligte Person: | REID, J. G ; RENY RUNGE, J. M |
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Zeitschrift: | Tetrahedron letters, Jg. 31 (1990), Heft 8, S. 1093-1096 |
Veröffentlichung: | Oxford: Elsevier, 1990 |
Medientyp: | academicJournal |
Umfang: | print, 7 ref |
ISSN: | 0040-4039 (print) |
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