Analysis of genetic polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese patients with therapy-related leukemia/ myelodysplastic syndrome and de novo acute myeloid leukemia

NAOE, Tomoki ; TAKEYAMA, Kunihiko ; et al.

In: Clinical cancer research, Jg. 6 (2000), Heft 10, S. 4091-4095

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Several genetic polymorphisms in metabolic activation or detoxification enzymes have been associated with susceptibility to therapy-related leukemia and myelodysplastic leukemia (TRL/MDS). We analyzed gene polymorphisms of NAD(P)H:quinone oxidoreductase (NQO1), glutathione S-tranferase (GST)-M1 and -Tl, and CYP3A4, the enzymes of which are capable of metabolizing anticancer drugs, in 58 patients with TRL/MDS and in 411 patients with de novo acute myeloid leukemia (AML). Homozygous Ser/Ser genotype of NQO1 at codon 187, causing loss of function, was more frequent in the patients with TRL/MDS (14 of 58, 24.1%; OR = 2.62) than in those with de novo AML (64 of 411, 15.6%), and control (16 of 150, 10.6%; P = 0.002). Allelic frequencies of NQO1 were different between TRL/ MDS and de novo AML (P = 0.01). In GST-M1 and -Tl, the incidence of homologous deletion was similar among the three groups. The polymorphism of the 5' promoter region of CYP3A4 was not found in persons of Japanese ethnicity. These results suggest that the NQO1 polymorphism is significantly associated with the genetic risk of TRL/MDS.

Titel:	Analysis of genetic polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese patients with therapy-related leukemia/ myelodysplastic syndrome and de novo acute myeloid leukemia
Autor/in / Beteiligte Person:	NAOE, Tomoki ; TAKEYAMA, Kunihiko ; KAMADA, Nanao ; KUBOTA, Yoshitsugu ; NAKAMURA, Hiroyuki ; SHIMAZAKI, Chihiro ; HORIIKE, Shigeo ; KODERA, Yoshihisa ; SAITO, Hidehiko ; UEDA, Ryuzo ; WIEMELS, Joseph ; OHNO, Ryuzo ; YOKOZAWA, Toshiya ; KIYOI, Hitoshi ; SETO, Masao ; UIKE, Naokuni ; INO, Teruo ; UTSUNOMIYA, Atae ; MARUTA, Atsuo ; JIN-NAI, Itsuro
Link:	Full Text Finder (Volltext) View record from PASCAL Archive
Zeitschrift:	Clinical cancer research, Jg. 6 (2000), Heft 10, S. 4091-4095
Veröffentlichung:	Philadelphia, PA: American Association for Cancer Research, 2000
Medientyp:	academicJournal
Umfang:	print, 35 ref
ISSN:	1078-0432 (print)
Schlagwort:	Asie Asia Japon Japan Japón Medical oncology Cancérologie Pharmacology drugs Pharmacologie, galénique Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Hemopathies Hematologic and hematopoietic diseases Leucémies. Lymphomes malins. Réticuloses malignes. Hématodermies. Splénomégalie myéloïde Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Enzyme Enzima Hémopathie maligne Malignant hemopathy Hemopatía maligna Oxidoreductases Transferases Activation métabolique Metabolic activation Activación metabólica Aigu Acute Agudo Anticancéreux Antineoplastic agent Anticanceroso Cytochrome P450 Citocromo P450 De novo Drug-metabolizing enzyme Détoxication Detoxication Detoxicación Facteur risque Risk factor Factor riesgo Glutathione transferase Génotype Genotype Genotipo Génétique Genetics Genética Homme Human Hombre In vitro Leucémie myéloblastique Acute myelocytic leukemia Leucemia mieloblástica Leucémie Leukemia Leucemia Myélodysplasique syndrome Myelodysplastic syndrome Mielodisplastico síndrome NADPH:quinone reductase Polymorphisme Polymorphism Polimorfismo Sang Blood Sangre Toxicité Toxicity Toxicidad Traitement Treatment Tratamiento Cytochrome CYP3A4 Gène GSTM1 Gène GSTT1 Gène NQO1 Subject Geographic: Asie Asia Japon Japan Japón
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Department of Infectious Diseases, Nagoya University School of Medicine, Nagoya 466-8560, Japan ; Department of Internal Medicine, Nagoya University School of Medicine, Nagoya 466-8560, Japan ; Department of Cancer Cytogenetics, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan ; Transfusion Medicine, School of Medicine, Kagawa Medical School, Kagawa 761-0793, Japan ; The Fifth Department of Internal Medicine, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan ; The Second Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan ; The Third Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan ; Department of Medicine, Japanese Red Cross, Nagoya First Hospital, Nagoya 453-8511, Japan ; The Second Department of Internal Medicine, Nagoya City University Medical School, Nagoya 467-8601, Japan ; Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94143-0560, Japan ; Department of Medicine III, Hamamatsu University School of Medicine, Hamamatsu, 431-3192, Japan ; Laboratory of Chemotherapy, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan ; Department of Hematology, National Kyushu Cancer Center, Fukuoka 811-1395, Japan ; Department of Medicine, Fujita Health University, School of Medicine, Toyowake 470-1192, Japan ; The Second Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Kagoshima 890-8520, Japan ; Department of Hematology, Kanagawa Cancer Center, Yokohama 241-0815, Japan ; Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine, Nagasaki 852-8523, Japan Rights: Copyright 2001 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Blood diseases

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