Dopamine transporter density in young patients with schizophrenia assessed with [123]FP-CIT SPECT
In: Schizophrenia research, Jg. 47 (2001), Heft 1, S. 59-67
academicJournal
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Zugriff:
Disturbances in the dopamine (DA) system are thought to play a major role in schizophrenia. Amphetamine-induced release of endogenous DA is shown to be enhanced in schizophrenia, as is striatal [18F]FDOPA uptake in the striatum. It is not clear if the density of DA neurons is altered in schizophrenia. By studying the DA transporter with [123I]FP-CIT single photon emission computed tomography (SPECT). the density of nigrostriatal dopaminergic cells can be studied. Using [123I]FP-CIT SPECT, DA transporter density in the striatum was studied in 36 young patients with schizophrenia. Ten patients were antipsychotic (AP)-naive, 15 were treated with olanzapine, eight with risperidone and three were AP-free. A control group of 10 age-matched volunteers was included. Striatal [123I]FP-CIT binding was not significantly different between AP-naive patients (2.87), patients treated with olanzapine (2.76), patients treated with risperidone (2.76), AP-free patients (2.68) and controls (2.82) (F = 0.07, p = 0.98). Unexpectedly, striatal [123I]FP-CIT binding in females was significantly higher than in males (3.29 and 2.70, respectively; t = -2.56, p = 0.014). Concluding, functional changes in the dopaminergic system in schizophrenia are not likely to be reflected in a change in DA transporter density. Moreover, DA transporter density does not seem to be altered by AP medication.
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Dopamine transporter density in young patients with schizophrenia assessed with [123]FP-CIT SPECT
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Autor/in / Beteiligte Person: | LAVALAYE, Jules ; LINSZEN, Don H ; BOOIJ, Jan ; DINGEMANS, Peter M. A. J ; RENEMAN, Liesbeth ; HABRAKEN, Jan B. A ; GERSONS, Berthold P. R ; VAN ROYEN, Eric A |
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Zeitschrift: | Schizophrenia research, Jg. 47 (2001), Heft 1, S. 59-67 |
Veröffentlichung: | Amsterdam: Elsevier Science, 2001 |
Medientyp: | academicJournal |
Umfang: | print, 1 p.1/4 |
ISSN: | 0920-9964 (print) |
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