Poly(D, L-lactide) foams modified by poly(ethylene oxide)-block-poly(D, L-lactide) copolymers and a-FGF: in vitro and in vivo evaluation for spinal cord regeneration

MAQUET, V ; MARTIN, D ; et al.

In: Neural tissue engineering, Jg. 22 (2001), Heft 10, S. 1137-1146

academicJournal - print, 21 ref

The first goal of this study was to examine the influence that poly(ethylene oxide)-block-poly(D,L-lactide)( (PELA) copolymer can have on the wettability, the in vitro controlled delivery capability, and the degradation of poly(D,L-lactide) (PDLLA) foams. These foams were prepared by freeze-drying and contain micropores (10 μm) in addition of macropores (100 μm) organized longitudinally. Weight loss, water absorption, changes in molecular weight, polymolecularity (Mw/Mn) and glass transition temperature (Tg) of PDLLA foams mixed with various amounts of PELA were followed with time. It was found that 10 wt% of PELA increased the wettability and the degradation rate of the polymer foams. The release of sulforhodamine (SR) was compared for PDLLA and PDLLA-PELA foams in relation with the foam porosity. An initial burst release was observed only in the case of the 90:10 PDLLA/PELA foam. The ability of the foam of this composition to be integrated and to promote tissue repair and axonal regeneration in the transected rat spinal cord was investigated. After implantation of ca. 20 polymer rods assembled with fibrin-glue, the polymer construct was able to bridge the cord stumps by forming a permissive support for cellular migration, angiogenesis and axonal regrowth.

Titel:	Poly(D, L-lactide) foams modified by poly(ethylene oxide)-block-poly(D, L-lactide) copolymers and a-FGF: in vitro and in vivo evaluation for spinal cord regeneration
Autor/in / Beteiligte Person:	MAQUET, V ; MARTIN, D ; SCHOLTES, F ; FRANZEN, R ; SCHOENEN, J ; MOONEN, G ; JEROME, R
Link:	E-Journal im Bestand der UB Hagen? View record from PASCAL Archive
Zeitschrift:	Neural tissue engineering, Jg. 22 (2001), Heft 10, S. 1137-1146
Veröffentlichung:	Oxford: Elsevier Science, 2001
Medientyp:	academicJournal
Umfang:	print, 21 ref
ISSN:	0142-9612 (print)
Schlagwort:	Biochemistry, molecular biology, biophysics Biochimie, biologie moléculaire, biophysique Biomedical engineering Génie biomédical Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Chirurgie (generalites). Transplantations, greffes d'organes et de tissus. Pathologie des greffons Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Chirurgie du système nerveux Neurosurgery Liquide céphalorachidien. Moelle épinière. Racines rachidiennes. Nerfs rachidiens Cerebrospinal fluid. Spinal cord. Spinal roots. Spinal nerves Ingeniería biomédica Mammalia Rodentia Vertebrata Animal Axone Axon Axón Copolymère séquencé Block copolymer Copolímero secuencia Dégradation Degradation Degradación Ethylène oxyde polymère Ethylene oxide polymer Etileno óxido polímero Facteur croissance fibroblaste acide Acidic fibroblast growth factor Factor crecimiento fibroblasto ácido Forme libération contrôlée Controlled release form Forma liberación controlada In vitro In vivo Lactique acide polymère Lactic acid polymer Láctico ácido polímero Moelle épinière Spinal cord Médula espinal Rat Rata Régénération Regeneration Regeneración Système nerveux central Central nervous system Sistema nervioso central
Sonstiges:	Nachgewiesen in: PASCAL Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Center for Education and Research on Macromolecules, University of Liège, Institute of Chemistry, B6, Sart-Tilman, 4000 Liège, Belgium ; Department of Neurosurgery, CHU, University of Liège, Belgium ; Department of Human Physiology and Physiopathology, University of Liège, Belgium ; Department of Neuroanatomy, CHU, University of Liège, Belgium Rights: Copyright 2001 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS Notes: Surgery (generalities). Transplants, organs and tissues grafting. Graft pathologies

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