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Antioxidants as Adjuvant Therapy to Standard Therapy in Patients With COVID-19 (ANTIOX-COVID)

Instituto Nacional de Cardiologia Ignacio Chavez ; Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran ; et al.
In: VankadarN, Wce JA. Emergg WuHan (COV-19) coronavus: glycan shld and structure predtn of spe glycoprote and s teractn wh human CD26. Emerg Mrobes fect. 2020 Mar 17;9(1):601-604. do 10.1080/22221751.2020.1739565. eCollectn 2020. rah , Abdelmalek DH, Elshahat ME, Elfy AA. COV-19 spe-host cell receptor GRP78 bdg se predtn. J fect. 2020 May;80(5):554-562. do 10.1016/j.jf.2020.02.026. Epub 2020 Mar 10. Neuman BW, Buchmer MJ. Supramolecular Archecture of the Coronavus Partle. Adv Vus Res. 2016;96:1-27. do 10.1016/bs.a.2016.08.005. Epub 2016 Sep 15. Seah Agrawal R. Can the Coronavus Dease 2019 (COV-19) Affect the Eyes? A Revw of Coronavuses and Ocular platns Humans and Anals. Ocul munol flamm. 2020 Apr 2;28(3):391-395. do 10.1080/09273948.2020.1738501. Epub 2020 Mar 16. Lung J, L YS, Yang YH, Chou YL, Shu LH, Cheng YC, L HT, Wu CY. The potentl chemal structure of antSARS-CoV-2 RNA-dependent RNA polymerase. J Med Vol. 2020 Jun;92(6):693-697. do 10.1002/jmv.25761. Epub 2020 Mar 18. Erratum : J Med Vol. 2020 Oct;92(10):2248. Sghal T. A Revw of Coronavus Dease-2019 (COV-19). dn J Pedtr. 2020 Apr;87(4):281-286. do 10.1007/s12098-020-03263-6. Epub 2020 Mar 13. Wang D, Hu B, Hu C, Zhu F, L X, Zhang J, Wang B, Xng H, Cheng Z, Xng Y, Zhao Y, LY, Wang X, Peng Z. Clal Characterts of 138 Hospaled Patnts Wh 2019 Novel Coronavus-fected Pneumon Wuhan, Cha. JAMA. 2020 Mar 17;323(11):1061-1069. do 10.1001/jama.2020.1585. Erratum : JAMA. 2021 Mar 16;325(11):1113. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Q Y, Wang J, L Y, WeY, X J, Yu T, Zhang X, Zhang L. Epemlogal and clal characterts of 99 cases of 2019 novel coronavus pneumon Wuhan, Cha: a descrte study. Lancet. 2020 Feb 15;395(10223):507-513. do 10.1016/S0140-6736(20)30211-7. Epub 2020 Jan 30. Leovz B, Sgel BV. Ascorb ac and the mune response. Adv Exp Med Bl. 1981;135:1-25. do 10.1007/978-1-4615-9200-6_1. No abstract avaable. Speer EM, Dowlg DJ, Ozog LS, Xu J, Yang J, Kennady G, Levy O. Pentoxylle hs TLR- and flammasome-medted vro flammatory cytoke productn human blood wh greater effacy and potency newborns. Pedtr Res. 2017 May;81(5):806-816. do 10.1038/pr.2017.6. Epub 2017 Jan 10. Rcrdolo FL, CaramorG, o K, CapellA, Brun P, Abatangelo G, PapA, Chung KF, Adcock Barnes PJ, Donner CF, RossA, DStefano A. Nrosate stress the bronchl mucosa of severe chron obstructe pulmonary dease. J Allergy Cl munol. 2005 Nov;116(5):1028-35. do 10.1016/j.jac2005.06.034. Epub 2005 Sep 28. Barnes PJ, o K, Adcock Cortostero restance chron obstructe pulmonary dease: actatn of htone deacetylase. Lancet. 2004 Feb 28;363(9410):731-3. do 10.1016/S0140-6736(04)15650-X. Sgh VP, Aggarwal R, Sgh S, Ban A, Ahmad T, Patna BR, Nappanveett G, Sgh KP, Aggarwal ML, Ghosh B, Agrawal A. Metabol Syndrome Assocted wh creased Oxo-Nrate Stress and Asthma-Le Changes Lungs. PLoS One. 2015 Jun 22;10(6):e0129850. do 10.1371/journal.pone.0129850. eCollectn 2015. Russell JA. Management of seps. N Engl J Med. 2006 Oct 19;355(16):1699-713. do 10.1056/NEJMra043632. No abstract avaable. Erratum : N Engl J Med. 2006 Nov 23;355(21):2267. Rers EP, Mctyre L, Morro DC, Rers KK. Early and novate terventns for severe seps and sept shock: takg advantage of a wdow of opportuny. CMAJ. 2005 Oct 25;173(9):1054-65. do 10.1503/cmaj.050632. Clapp BR, HgoranAD, Kharbanda RK, Mohamed-AlV, Stephens JW, Vallance P, MacAllter RJ. flammatn-duced endothell dysfunctn volves reduced nr oxe bavaaby and creased oxant stress. Cardvasc Res. 2004 Oct 1;64(1):172-8. do 10.1016/j.cardres.2004.06.020. Perez-Torres Manzano-Pech L, Rub-Ru ME, Soto ME, Guarner-Lans V. Nrosate Stress and s Assoctn wh Cardmetabol Dorders. Molecules. 2020 May 31;25(11):2555. do 10.3390/molecules25112555. L Z, Yg Y. The hory Effect of Curcum on Vus-duced Cytoke Storm and s Potentl Use the Assocted Severe Pneumon. Front Cell Dev Bl. 2020 Jun 12;8:479. do 10.3389/fcell.2020.00479. eCollectn 2020. Rahman I, MacNee W. Regulation of redox glutathione levels and gene transcription in lung inflammation: therapeutic approaches. Free Radic Biol Med. 2000 May 1;28(9):1405-20. doi: 10.1016/s0891-5849(00)00215-x. Paterson RL, Galley HF, Webster NR. The effect of N-acetylcysteine on nuclear factor-kappa B activation, interleukin-6, interleukin-8, and intercellular adhesion molecule-1 expression in patients with sepsis. Crit Care Med. 2003 Nov;31(11):2574-8. doi: 10.1097/01.CCM.0000089945.69588.18. Moradi M, Mojtahedzadeh M, Mandegari A, Soltan-Sharifi MS, Najafi A, Khajavi MR, Hajibabayee M, Ghahremani MH. The role of glutathione-S-transferase polymorphisms on clinical outcome of ALI/ARDS patient treated with N-acetylcysteine. Respir Med. 2009 Mar;103(3):434-41. doi: 10.1016/j.rmed.2008.09.013. Epub 2008 Nov 7. Peake SL, Moran JL, Leppard PI. N-acetyl-L-cysteine depresses cardiac performance in patients with septic shock. Crit Care Med. 1996 Aug;24(8):1302-10. doi: 10.1097/00003246-199608000-00006. Escames G, Guerrero JM, Reiter RJ, Garcia JJ, Munoz-Hoyos A, Ortiz GG, Oh CS. Melatonin and vitamin E limit nitric oxide-induced lipid peroxidation in rat brain homogenates. Neurosci Lett. 1997 Jul 25;230(3):147-50. doi: 10.1016/s0304-3940(97)00498-9. Galano A, Tan DX, Reiter RJ. Melatonin as a natural ally against oxidative stress: a physicochemical examination. J Pineal Res. 2011 Aug;51(1):1-16. doi: 10.1111/j.1600-079X.2011.00916.x. Hemila H, Douglas RM. Vitamin C and acute respiratory infections. Int J Tuberc Lung Dis. 1999 Sep;3(9):756-61. Shabaan AE, Nasef N, Shouman B, Nour I, Mesbah A, Abdel-Hady H. Pentoxifylline therapy for late-onset sepsis in preterm infants: a randomized controlled trial. Pediatr Infect Dis J. 2015 Jun;34(6):e143-8. doi: 10.1097/INF.0000000000000698. Akdag A, Dilmen U, Haque K, Dilli D, Erdeve O, Goekmen T. Role of pentoxifylline and/or IgM-enriched intravenous immunoglobulin in the management of neonatal sepsis. Am J Perinatol. 2014 Nov;31(10):905-12. doi: 10.1055/s-0033-1363771. Epub 2014 Feb 10. Fowler AA 3rd, Truwit JD, Hite RD, Morris PE, DeWilde C, Priday A, Fisher B, Thacker LR 2nd, Natarajan R, Brophy DF, Sculthorpe R, Nanchal R, Syed A, Sturgill J, Martin GS, Sevransky J, Kashiouris M, Hamman S, Egan KF, Hastings A, Spencer W, Tench S, Mehkri O, Bindas J, Duggal A, Graf J, Zellner S, Yanny L, McPolin C, Hollrith T, Kramer D, Ojielo C, Damm T, Cassity E, Wieliczko A, Halquist M. Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial. JAMA. 2019 Oct 1;322(13):1261-1270. doi: 10.1001/jama.2019.11825. Erratum In: JAMA. 2020 Jan 28;323(4):379. Protti A, Singer M. Bench-to-bedside review: potential strategies to protect or reverse mitochondrial dysfunction in sepsis-induced organ failure. Crit Care. 2006;10(5):228. doi: 10.1186/cc5014. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonca A, Bruining H, Reinhart CK, Suter PM, Thijs LG. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med. 1996 Jul;22(7):707-10. doi: 10.1007/BF01709751. No abstract available. Open Clinical Trial of the Use of Antioxidants and Pentoxifylline as Adjuvant Therapy to Standard Therapy in Patients With and Without Septic Shock Secondary to COVID-19 Severe Pneumonia
Online report

Titel:
Antioxidants as Adjuvant Therapy to Standard Therapy in Patients With COVID-19 (ANTIOX-COVID)
Autor/in / Beteiligte Person: Instituto Nacional de Cardiologia Ignacio Chavez ; Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran ; Adrian Palacios-Chavarria, MD, Principal investigator
Link:
Quelle: VankadarN, Wce JA. Emergg WuHan (COV-19) coronavus: glycan shld and structure predtn of spe glycoprote and s teractn wh human CD26. Emerg Mrobes fect. 2020 Mar 17;9(1):601-604. do 10.1080/22221751.2020.1739565. eCollectn 2020. rah , Abdelmalek DH, Elshahat ME, Elfy AA. COV-19 spe-host cell receptor GRP78 bdg se predtn. J fect. 2020 May;80(5):554-562. do 10.1016/j.jf.2020.02.026. Epub 2020 Mar 10. Neuman BW, Buchmer MJ. Supramolecular Archecture of the Coronavus Partle. Adv Vus Res. 2016;96:1-27. do 10.1016/bs.a.2016.08.005. Epub 2016 Sep 15. Seah Agrawal R. Can the Coronavus Dease 2019 (COV-19) Affect the Eyes? A Revw of Coronavuses and Ocular platns Humans and Anals. Ocul munol flamm. 2020 Apr 2;28(3):391-395. do 10.1080/09273948.2020.1738501. Epub 2020 Mar 16. Lung J, L YS, Yang YH, Chou YL, Shu LH, Cheng YC, L HT, Wu CY. The potentl chemal structure of antSARS-CoV-2 RNA-dependent RNA polymerase. J Med Vol. 2020 Jun;92(6):693-697. do 10.1002/jmv.25761. Epub 2020 Mar 18. Erratum : J Med Vol. 2020 Oct;92(10):2248. Sghal T. A Revw of Coronavus Dease-2019 (COV-19). dn J Pedtr. 2020 Apr;87(4):281-286. do 10.1007/s12098-020-03263-6. Epub 2020 Mar 13. Wang D, Hu B, Hu C, Zhu F, L X, Zhang J, Wang B, Xng H, Cheng Z, Xng Y, Zhao Y, LY, Wang X, Peng Z. Clal Characterts of 138 Hospaled Patnts Wh 2019 Novel Coronavus-fected Pneumon Wuhan, Cha. JAMA. 2020 Mar 17;323(11):1061-1069. do 10.1001/jama.2020.1585. Erratum : JAMA. 2021 Mar 16;325(11):1113. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Q Y, Wang J, L Y, WeY, X J, Yu T, Zhang X, Zhang L. Epemlogal and clal characterts of 99 cases of 2019 novel coronavus pneumon Wuhan, Cha: a descrte study. Lancet. 2020 Feb 15;395(10223):507-513. do 10.1016/S0140-6736(20)30211-7. Epub 2020 Jan 30. Leovz B, Sgel BV. Ascorb ac and the mune response. Adv Exp Med Bl. 1981;135:1-25. do 10.1007/978-1-4615-9200-6_1. No abstract avaable. Speer EM, Dowlg DJ, Ozog LS, Xu J, Yang J, Kennady G, Levy O. Pentoxylle hs TLR- and flammasome-medted vro flammatory cytoke productn human blood wh greater effacy and potency newborns. Pedtr Res. 2017 May;81(5):806-816. do 10.1038/pr.2017.6. Epub 2017 Jan 10. Rcrdolo FL, CaramorG, o K, CapellA, Brun P, Abatangelo G, PapA, Chung KF, Adcock Barnes PJ, Donner CF, RossA, DStefano A. Nrosate stress the bronchl mucosa of severe chron obstructe pulmonary dease. J Allergy Cl munol. 2005 Nov;116(5):1028-35. do 10.1016/j.jac2005.06.034. Epub 2005 Sep 28. Barnes PJ, o K, Adcock Cortostero restance chron obstructe pulmonary dease: actatn of htone deacetylase. Lancet. 2004 Feb 28;363(9410):731-3. do 10.1016/S0140-6736(04)15650-X. Sgh VP, Aggarwal R, Sgh S, Ban A, Ahmad T, Patna BR, Nappanveett G, Sgh KP, Aggarwal ML, Ghosh B, Agrawal A. Metabol Syndrome Assocted wh creased Oxo-Nrate Stress and Asthma-Le Changes Lungs. PLoS One. 2015 Jun 22;10(6):e0129850. do 10.1371/journal.pone.0129850. eCollectn 2015. Russell JA. Management of seps. N Engl J Med. 2006 Oct 19;355(16):1699-713. do 10.1056/NEJMra043632. No abstract avaable. Erratum : N Engl J Med. 2006 Nov 23;355(21):2267. Rers EP, Mctyre L, Morro DC, Rers KK. Early and novate terventns for severe seps and sept shock: takg advantage of a wdow of opportuny. CMAJ. 2005 Oct 25;173(9):1054-65. do 10.1503/cmaj.050632. Clapp BR, HgoranAD, Kharbanda RK, Mohamed-AlV, Stephens JW, Vallance P, MacAllter RJ. flammatn-duced endothell dysfunctn volves reduced nr oxe bavaaby and creased oxant stress. Cardvasc Res. 2004 Oct 1;64(1):172-8. do 10.1016/j.cardres.2004.06.020. Perez-Torres Manzano-Pech L, Rub-Ru ME, Soto ME, Guarner-Lans V. Nrosate Stress and s Assoctn wh Cardmetabol Dorders. Molecules. 2020 May 31;25(11):2555. do 10.3390/molecules25112555. L Z, Yg Y. The hory Effect of Curcum on Vus-duced Cytoke Storm and s Potentl Use the Assocted Severe Pneumon. Front Cell Dev Bl. 2020 Jun 12;8:479. do 10.3389/fcell.2020.00479. eCollectn 2020. Rahman I, MacNee W. Regulation of redox glutathione levels and gene transcription in lung inflammation: therapeutic approaches. Free Radic Biol Med. 2000 May 1;28(9):1405-20. doi: 10.1016/s0891-5849(00)00215-x. Paterson RL, Galley HF, Webster NR. The effect of N-acetylcysteine on nuclear factor-kappa B activation, interleukin-6, interleukin-8, and intercellular adhesion molecule-1 expression in patients with sepsis. Crit Care Med. 2003 Nov;31(11):2574-8. doi: 10.1097/01.CCM.0000089945.69588.18. Moradi M, Mojtahedzadeh M, Mandegari A, Soltan-Sharifi MS, Najafi A, Khajavi MR, Hajibabayee M, Ghahremani MH. The role of glutathione-S-transferase polymorphisms on clinical outcome of ALI/ARDS patient treated with N-acetylcysteine. Respir Med. 2009 Mar;103(3):434-41. doi: 10.1016/j.rmed.2008.09.013. Epub 2008 Nov 7. Peake SL, Moran JL, Leppard PI. N-acetyl-L-cysteine depresses cardiac performance in patients with septic shock. Crit Care Med. 1996 Aug;24(8):1302-10. doi: 10.1097/00003246-199608000-00006. Escames G, Guerrero JM, Reiter RJ, Garcia JJ, Munoz-Hoyos A, Ortiz GG, Oh CS. Melatonin and vitamin E limit nitric oxide-induced lipid peroxidation in rat brain homogenates. Neurosci Lett. 1997 Jul 25;230(3):147-50. doi: 10.1016/s0304-3940(97)00498-9. Galano A, Tan DX, Reiter RJ. Melatonin as a natural ally against oxidative stress: a physicochemical examination. J Pineal Res. 2011 Aug;51(1):1-16. doi: 10.1111/j.1600-079X.2011.00916.x. Hemila H, Douglas RM. Vitamin C and acute respiratory infections. Int J Tuberc Lung Dis. 1999 Sep;3(9):756-61. Shabaan AE, Nasef N, Shouman B, Nour I, Mesbah A, Abdel-Hady H. Pentoxifylline therapy for late-onset sepsis in preterm infants: a randomized controlled trial. Pediatr Infect Dis J. 2015 Jun;34(6):e143-8. doi: 10.1097/INF.0000000000000698. Akdag A, Dilmen U, Haque K, Dilli D, Erdeve O, Goekmen T. Role of pentoxifylline and/or IgM-enriched intravenous immunoglobulin in the management of neonatal sepsis. Am J Perinatol. 2014 Nov;31(10):905-12. doi: 10.1055/s-0033-1363771. Epub 2014 Feb 10. Fowler AA 3rd, Truwit JD, Hite RD, Morris PE, DeWilde C, Priday A, Fisher B, Thacker LR 2nd, Natarajan R, Brophy DF, Sculthorpe R, Nanchal R, Syed A, Sturgill J, Martin GS, Sevransky J, Kashiouris M, Hamman S, Egan KF, Hastings A, Spencer W, Tench S, Mehkri O, Bindas J, Duggal A, Graf J, Zellner S, Yanny L, McPolin C, Hollrith T, Kramer D, Ojielo C, Damm T, Cassity E, Wieliczko A, Halquist M. Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial. JAMA. 2019 Oct 1;322(13):1261-1270. doi: 10.1001/jama.2019.11825. Erratum In: JAMA. 2020 Jan 28;323(4):379. Protti A, Singer M. Bench-to-bedside review: potential strategies to protect or reverse mitochondrial dysfunction in sepsis-induced organ failure. Crit Care. 2006;10(5):228. doi: 10.1186/cc5014. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonca A, Bruining H, Reinhart CK, Suter PM, Thijs LG. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med. 1996 Jul;22(7):707-10. doi: 10.1007/BF01709751. No abstract available. Open Clinical Trial of the Use of Antioxidants and Pentoxifylline as Adjuvant Therapy to Standard Therapy in Patients With and Without Septic Shock Secondary to COVID-19 Severe Pneumonia
Medientyp: report
Sonstiges:
  • Nachgewiesen in: ClinicalTrials.gov
  • Sprachen: English

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