Lipo-MGN nanoparticle hypoxia attenuation-mediated single-dose radiotherapy- and pH/ROS-responsive T1 contrast magnetic resonance imaging in hepatocellular carcinoma
In: Cancer Nanotechnology, Jg. 14 (2023), Heft 1, S. 1-17
Online
academicJournal
Zugriff:
Abstract Tumor hypoxia is an important factor for developing resistance to radiation therapy (RT) and presents a bleak prognosis in cancer patients undergoing treatment for RT resistant hepatocellular carcinoma. Here, we present the synthesis of liposome-coated Mn3O4 (MGN) nanoparticles (Lipo-MGN) and investigation of their therapeutic potential with RT utilizing a HepG2 cancer model. According to in vitro research, Lipo-MGN effectively produced oxygen in the presence of H2O2 and significantly reduced the expression of HIF-1 in human HepG2 cells that were under hypoxic conditions. Lipo-MGN reversed the radio-resistance brought on by hypoxia and increased cell damage. When Lipo-MGN and RT were administered together in a HepG2 xenograft mice model, the tumor growth was delayed more than with RT alone. As determined by MR imaging, liposome-MGN also exhibited T1 contrast enhancement in tumor. According to these findings, Lipo-MGNs may increase the impact of RT by focusing tumor hypoxia. Hypoxic, radioresistant HepG2 cancer may be treated with Lipo-MGN in clinical studies.
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Lipo-MGN nanoparticle hypoxia attenuation-mediated single-dose radiotherapy- and pH/ROS-responsive T1 contrast magnetic resonance imaging in hepatocellular carcinoma
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Autor/in / Beteiligte Person: | Reju George Thomas ; Kim, Subin ; Nagareddy, Raveena ; Vijayan, Veena ; Ansuja Mathew Pullickal ; Mee Sun Yoon ; In Kyu Park ; Yong Yeon Jeong |
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Zeitschrift: | Cancer Nanotechnology, Jg. 14 (2023), Heft 1, S. 1-17 |
Veröffentlichung: | BMC, 2023 |
Medientyp: | academicJournal |
ISSN: | 1868-6958 (print) ; 1868-6966 (print) |
DOI: | 10.1186/s12645-023-00182-x |
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