ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors
In: Nature Communications, Jg. 14 (2023), Heft 1, S. 1-19
Online
academicJournal
Zugriff:
CDKN2A loss and p53 mutations are rare in MYC-driven Group 3 medulloblastomas (MBs). Here the authors generated a transgenic mouse model of Group 3 MB by MYC overexpression and show that MYC suppresses ARF to drive tumorigenesis.
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ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors
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Autor/in / Beteiligte Person: | Mainwaring, Oliver J. ; Weishaupt, Holger ; Zhao, Miao ; Rosén, Gabriela ; Borgenvik, Anna ; Breinschmid, Laura ; Verbaan, Annemieke D. ; Richardson, Stacey ; Thompson, Dean ; Clifford, Steven C. ; Hill, Rebecca M. ; Annusver, Karl ; Sundström, Anders ; Holmberg, Karl O. ; Kasper, Maria ; Hutter, Sonja ; Swartling, Fredrik J. |
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Zeitschrift: | Nature Communications, Jg. 14 (2023), Heft 1, S. 1-19 |
Veröffentlichung: | Nature Portfolio, 2023 |
Medientyp: | academicJournal |
ISSN: | 2041-1723 (print) |
DOI: | 10.1038/s41467-023-36847-9 |
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