HNA specificity and association to HLA-DRB1 and -DQB1 in patients with autoimmune neutropenia of early childhood
In: Clinical Immunology Communications, Jg. 3 (2023-12-01), Heft 31-36, S. 31-36
Online
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Zugriff:
Autoimmune neutropenia (AIN) of early childhood is caused by autoantibodies against antigens on the neutrophil membrane. Human leukocyte antigens (HLA) have previously been associated with AIN. This study investigated HLA-DRB1 and HLA-DQB1 alleles in 160 antibody positive patients and compared with 1000 controls. Increased risk was observed for DRB1*10, DRB1*14, DRB1*16 and DQB1*05, and lower risk for DRB1*04, DRB1*13 and DQB1*03. Haplotypes with higher risk included: DRB1*10/DQB1*05, DRB1*14/DQB1*05 and DRB1*16/DQB1*05, while DRB1*04/DQB1*03, DRB1*07/DQB1*02, and DRB1*13/DQB1*06 were associated with lower risk. Associated HLA-DRB1 and –DQB1 differed between patients positive for anti-HNA-1a-specific antibodies and patients positive for broad reactive anti-FcγRIIIb antibodies. DRB1*01, DRB1*04 and DQB1*03 was only associated for anti-HNA-1a positive, and DRB1*10 was restricted to broad reactive anti-FcγRIIIb positive. Strong association between AIN and HLA-DRB1 and -DQB1 alleles and haplotypes suggested that they play a role in susceptibility or protection. Different associations regarding FcγRIIIb antibody specificities could indicate disease heterogeneity.
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HNA specificity and association to HLA-DRB1 and -DQB1 in patients with autoimmune neutropenia of early childhood
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Autor/in / Beteiligte Person: | Kløve-Mogensen, Kirstine ; Steffensen, Rudi ; Hans Linde Nielsen ; Tania Nicole Masmas ; Glenthøj, Andreas ; Christina Friis Jensen ; Thure Mors Haunstrup ; Ratcliffe, Paul ; Höglund, Petter ; Hasle, Henrik ; Kaspar René Nielsen |
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Zeitschrift: | Clinical Immunology Communications, Jg. 3 (2023-12-01), Heft 31-36, S. 31-36 |
Veröffentlichung: | Elsevier, 2023 |
Medientyp: | academicJournal |
ISSN: | 2772-6134 (print) |
DOI: | 10.1016/j.clicom.2023.02.002 |
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