Cerebrospinal fluid oligoclonal bands in Chinese patients with multiple sclerosis: the prevalence and its association with clinical features
In: Frontiers in Immunology, Jg. 14 (2023-11-01)
Online
academicJournal
Zugriff:
BackgroundCerebrospinal fluid oligoclonal band (CSF-OCB) is an established biomarker in diagnosing multiple sclerosis (MS), however, there are no nationwide data on CSF-OCB prevalence and its diagnostic performance in Chinese MS patients, especially in the virtue of common standard operation procedure (SOP).MethodsWith a consensus SOP and the same isoelectric focusing system, we conducted a nationwide multi-center study on OCB status in consecutively, and recruited 483 MS patients and 880 non-MS patients, including neuro-inflammatory diseases (NID, n = 595) and non-inflammatory neurological diseases (NIND, n=285). Using a standardized case report form (CRF) to collect the clinical, radiological, immunological, and CSF data, we explored the association of CSF-OCB positivity with patient characters and the diagnostic performance of CSF-OCB in Chinese MS patients. Prospective source data collection, and retrospective data acquisition and statistical data analysis were used.Findings369 (76.4%) MS patients were OCB-positive, while 109 NID patients (18.3%) and 6 NIND patients (2.1%) were OCB-positive, respectively. Time from symptom onset to diagnosis was significantly shorter in OCB-positive than that in OCB-negative MS patients (13.2 vs 23.7 months, P=0.020). The prevalence of CSF-OCB in Chinese MS patients was significantly higher in high-latitude regions (41°-50°N)(P=0.016), and at high altitudes (>1000m)(P=0.025). The diagnostic performance of CSF-OCB differentiating MS from non-MS patients yielded a sensitivity of 76%, a specificity of 87%.InterpretationThe nationwide prevalence of CSF-OCB was 76.4% in Chinese MS patients, and demonstrated a good diagnostic performance in differentiating MS from other CNS diseases. The CSF-OCB prevalence showed a correlation with high latitude and altitude in Chinese MS patients.
Titel: |
Cerebrospinal fluid oligoclonal bands in Chinese patients with multiple sclerosis: the prevalence and its association with clinical features
|
---|---|
Autor/in / Beteiligte Person: | Zhang, Xiang ; Hao, Hongjun ; Jin, Tao ; Qiu, Wei ; Yang, Huan ; Xue, Qun ; Yin, Jian ; Shi, Ziyan ; Yu, Hai ; Ji, Xiaopei ; Sun, Xiaobo ; Zeng, Qiuming ; Liu, Xiaoni ; Wang, Jingguo ; Li, Huining ; He, Xiaoyan ; Yang, Jing ; Li, Yarong ; Liu, Shuangshuang ; Lau, Alexander Y. ; Gao, Feng ; Hu, Shimin ; Chu, Shuguang ; Ding, Ding ; Zhou, Hongyu ; Li, Haifeng ; Chen, Xiangjun |
Link: | |
Zeitschrift: | Frontiers in Immunology, Jg. 14 (2023-11-01) |
Veröffentlichung: | Frontiers Media S.A., 2023 |
Medientyp: | academicJournal |
ISSN: | 1664-3224 (print) |
DOI: | 10.3389/fimmu.2023.1280020 |
Schlagwort: |
|
Sonstiges: |
|