FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase
In: eLife, Jg. 4 (2015-09-01)
Online
academicJournal
Zugriff:
Aberrant activation of anaplastic lymphoma kinase (ALK) has been described in a range of human cancers, including non-small cell lung cancer and neuroblastoma (Hallberg and Palmer, 2013). Vertebrate ALK has been considered to be an orphan receptor and the identity of the ALK ligand(s) is a critical issue. Here we show that FAM150A and FAM150B are potent ligands for human ALK that bind to the extracellular domain of ALK and in addition to activation of wild-type ALK are able to drive 'superactivation' of activated ALK mutants from neuroblastoma. In conclusion, our data show that ALK is robustly activated by the FAM150A/B ligands and provide an opportunity to develop ALK-targeted therapies in situations where ALK is overexpressed/activated or mutated in the context of the full length receptor.
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FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase
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| Autor/in / Beteiligte Person: | Guan, Jikui ; Umapathy, Ganesh ; Yamazaki, Yasuo ; Wolfstetter, Georg ; Mendoza, Patricia ; Pfeifer, Kathrin ; Mohammed, Ateequrrahman ; Hugosson, Fredrik ; Zhang, Hongbing ; Amy W Hsu ; Halenbeck, Robert ; Hallberg, Bengt ; Ruth H Palmer |
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| Zeitschrift: | eLife, Jg. 4 (2015-09-01) |
| Veröffentlichung: | eLife Sciences Publications Ltd, 2015 |
| Medientyp: | academicJournal |
| ISSN: | 2050-084X (print) |
| DOI: | 10.7554/eLife.09811 |
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