Cucurbitacin-B instigates intrinsic apoptosis and modulates Notch signaling in androgen-dependent prostate cancer LNCaP cells
In: Frontiers in Pharmacology, Jg. 14 (2023-06-01)
Online
academicJournal
Zugriff:
Introduction: Among numerous triterpenoids of the Cucurbitaceae family, Cucurbitacin-B (Cur-B) is being explored for its pharmacological attributes. Reports from previous studies have explicitly shown that Cur-B possesses substantial anticancer effects. The present report focuses on exploring the anticancer attributes of Cur-B against androgen-dependent PCa LNCaP cells.Methods: LNCaP cells were exposed to commercially available purified Cur-B at varying concentrations that were selected as 5, 10, 15, 20, and 25 µM for some time of 24 h to perform various experimental studies.Results: Cytotoxicity evaluation revealed that Cur-B impeded the LNCaP cell’s viability at 5 µM (p
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Cucurbitacin-B instigates intrinsic apoptosis and modulates Notch signaling in androgen-dependent prostate cancer LNCaP cells
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Autor/in / Beteiligte Person: | Alafnan, Ahmed ; Khalifa, Nasrin E. ; Hussain, Talib ; Mhdia Elhadi Osman |
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Zeitschrift: | Frontiers in Pharmacology, Jg. 14 (2023-06-01) |
Veröffentlichung: | Frontiers Media S.A., 2023 |
Medientyp: | academicJournal |
ISSN: | 1663-9812 (print) |
DOI: | 10.3389/fphar.2023.1206981 |
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