Evaluation of the Relationship between T2*CMR and Cardiac Depolarization and Repolarization Parameters in Beta-Thalassemia Patients

Background: Cardiac iron overload causes severe cardiac complications and is a leading cause of death in beta-thalassemia major patient. T2*CMR can detect preclinical cardiac iron overload. We evaluated the ability of 12-lead electrocardiographic atrial and ventricular depolarization and repolarization parameters to predict cardiac iron loading in TM.Materials and methods: This cross-sectional study was conducted on Patients with Beta thalassemia major; all participants underwent standard 12 lead electrocardiogram during a single study visit and the depolarization and repolarization parameters of ECG were measured and compared to the cardiac iron level detected by T2*CMR, with a detectable cardiac iron cutoff of T2*less than 20 ms.Results: A total of 26 patients (mean 26.19 years old, 34.62% male) were included. Mean T2*CMR values were 21.53 ms (46.15%