Generation of a human induced pluripotent stem cell line PUMCHi017-A from a Choroideremia patient with CHM mutation
In: Stem Cell Research, Jg. 59 (2022-03-01), Heft 102661-
Online
academicJournal
Zugriff:
Choroideremia (CHM) is a rare monogenic, X-linked recessive inherited chorioretinal dystrophy caused by loss of function variants in the CHM gene. We successfully generated a novel human induced pluripotent stem cell (hiPSC) line from a CHM patient with CHM variant using the Sendai-virus based approach. These cells will provide a disease model for further studies on the disease pathogenesis and potential interventions.
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Generation of a human induced pluripotent stem cell line PUMCHi017-A from a Choroideremia patient with CHM mutation
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Autor/in / Beteiligte Person: | Han, Xiaoxu ; Wu, Shijing ; Sun, Zixi ; Zhu, Tian ; Wei, Xing ; Zou, Xuan ; Sui, Ruifang |
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Zeitschrift: | Stem Cell Research, Jg. 59 (2022-03-01), Heft 102661- |
Veröffentlichung: | Elsevier, 2022 |
Medientyp: | academicJournal |
ISSN: | 1873-5061 (print) |
DOI: | 10.1016/j.scr.2022.102661 |
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