Light Deprivation Induces Depression-Like Behavior and Suppresses Neurogenesis in Diurnal Mongolian Gerbil ()
In: Cell Transplantation, Jg. 20 (2011-07-01)
Online
academicJournal
Zugriff:
Recent evidence suggests that adult neurogenesis contributes to the pathophysiology of different psychiatric disorders, including depressive disorder, anxiety disorder, and schizophrenia. Seasonal affective disorder (SAD) is a specific form of recurrent depressive disorder that can be induced by shortened light period. It is unclear yet whether neurogenesis is affected in SAD or under altered light/dark cycle. The present study aims at examining whether neurogenesis and dendritic growth of immature neurons are affected in Mongolian gerbils, a mainly diurnal rodent, under light deprivation. Animals were divided into two groups: the control (kept in 12 h light:12 h dark) and the light-deprived groups (kept in 24 h dark). Depression-like behaviors and neurogenesis were assessed after 2 weeks. Compared with the control group, light-deprived gerbils showed increased immobile time in the tail suspension test and forced swimming test, which indicates induction of depression-like behavior. Cell proliferation in both the hippocampal and subventricular zone were significantly decreased in the light-deprived group, which also showed a decreased neuronal differentiation. Dendritic maturation of immature neurons was suppressed by light deprivation, which is revealed by doublecortin staining and Sholl analysis. The results revealed that the light/dark cycle exerts impacts on neurogenesis and maturation of new neurons. Additionally, the current experiment may offer a model for exploring the relationship among daylight exposure, circadian cycles, depressive behavior, and the underlying mechanisms.
Titel: |
Light Deprivation Induces Depression-Like Behavior and Suppresses Neurogenesis in Diurnal Mongolian Gerbil ()
|
---|---|
Autor/in / Beteiligte Person: | Benson Wui-Man Lau ; Ren, Chaoran ; Yang, Jian ; Yan, Sylvia W. L. ; Raymond Chuen-Chung Chang ; Pu, Mingliang ; So, Kwok-Fai |
Link: | |
Zeitschrift: | Cell Transplantation, Jg. 20 (2011-07-01) |
Veröffentlichung: | SAGE Publishing, 2011 |
Medientyp: | academicJournal |
ISSN: | 0963-6897 (print) ; 1555-3892 (print) |
DOI: | 10.3727/096368910X539065 |
Schlagwort: |
|
Sonstiges: |
|