Green processing of thermosensitive nanocurcumin-encapsulated chitosan hydrogel towards biomedical application
In: Green Processing and Synthesis, Jg. 5 (2016), Heft 6, S. 511-520
Online
academicJournal
Zugriff:
In this study, in order to enhance the aqueous solubility and to overcome the limitation of curcumin (Cur) in free form, as well as to develop a carrier for transdermal delivery of hydrophobic pharmaceutical agents such as Cur, a sonicated synthetic process of nanocurcumin (nCur) in thermally responsive Chitosan-g-Pluronic (CP) copolymer is disclosed herein. The use of CP copolymer solution as a dispersant medium is a very attractive method to avoid the use of toxic organic solvent and non-biocompatible surfactant. The obtained Cur nanoparticles had a fairly narrow distribution of 8–23 nm. nCur-dispersed CP solution showed good stability with no change in color characteristic and no phase separation after 1 month of storage. Rheological characterization of CP hydrogels had indicated sol-gel transition at the same temperature (35°C). Interestingly, the rate of Cur release for this system can be conveniently modulated as transdermal drug delivery.
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Green processing of thermosensitive nanocurcumin-encapsulated chitosan hydrogel towards biomedical application
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Autor/in / Beteiligte Person: | Nguyen Thi Bich Tram ; Dang Le Hang ; Nguyen Thi Thanh Thuy ; Tran Dai Lam ; Nguyen Dai Hai ; Nguyen Van Toan ; Nguyen Cuu Khoa ; Nguyen Thi Hiep ; Le Van Thu ; Tran Ngoc Quyen |
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Zeitschrift: | Green Processing and Synthesis, Jg. 5 (2016), Heft 6, S. 511-520 |
Veröffentlichung: | De Gruyter, 2016 |
Medientyp: | academicJournal |
ISSN: | 2191-9542 (print) ; 2191-9550 (print) ; 2016-0062 (print) |
DOI: | 10.1515/gps-2016-0062 |
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