Clinical Significance of Excess Lactose in the Diet (Part 2)
In: Zdorovʹe Rebenka, Jg. 11 (2016), Heft 2.70, S. 150-157
Online
academicJournal
Zugriff:
The article on the basis of published data presents the ideas about the clinical significance of excess lactose in the diet. Lactose is a specific inhibitor of β-galactoside-binding protein — galectin-9 (Gal-9) which regulates the intracellular metabolism (cell growth, inflammation, immune response, apoptosis). Lactose, competitively binding to Gal-9, prevents activation of Gal-9/TIM-3-associated signaling pathways that promotes proliferation of the T-helper 1 and 17 cells, causing the induction of inflammation. Excess lactose reduces Treg-cells representation, which have immunosuppressive action, and increases insulin resistance. Lactose inhibits the interaction of Gal-9 with immunoglobulin E and hyaluronan-binding molecule CD44 and contributes to allergic manifestations. The limitations of using exogenous lactase preparations for pathognomonic treatment of inflammatory and allergic diseases in children with lactase deficiency are presented.
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Clinical Significance of Excess Lactose in the Diet (Part 2)
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Autor/in / Beteiligte Person: | Abaturov, O.Ye. ; Nikulina, A.O. |
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Zeitschrift: | Zdorovʹe Rebenka, Jg. 11 (2016), Heft 2.70, S. 150-157 |
Veröffentlichung: | Zaslavsky O.Yu., 2016 |
Medientyp: | academicJournal |
ISSN: | 2224-0551 (print) ; 2307-1168 (print) |
DOI: | 10.22141/2224-0551.2.70.2016.73840 |
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