Human Salmonella and Concurrent Decreased Susceptibility to Quinolones and Extended-Spectrum Cephalosporins
In: Emerging Infectious Diseases, Jg. 13 (2007), Heft 11, S. 1681-1688
Online
academicJournal
Zugriff:
The National Antimicrobial Resistance Monitoring System monitors susceptibility among Enterobacteriaceae in humans in the United States. We studied isolates exhibiting decreased susceptibility to quinolones (nalidixic acid MIC >32 µg/mL or ciprofloxacin MIC >0.12 µg/mL) and extended-spectrum cephalosporins (ceftiofur or ceftriaxone MIC >2 µg/mL) during 1996–2004. Of non-Typhi Salmonella, 0.19% (27/14,043) met these criteria: 11 Senftenberg; 6 Typhimurium; 3 Newport; 2 Enteridis; and 1 each Agona, Haifa, Mbandaka, Saintpaul, and Uganda. Twenty-six isolates had gyrA mutations (11 at codon 83 only, 3 at codon 87 only, 12 at both). All Senftenberg isolates had parC mutations (S80I and T57S); 6 others had the T57S mutation. The Mbandaka isolate contained qnrB2. Eight isolates contained blaCMY-2; 1 Senftenberg contained blaCMY-23. One Senftenberg and 1Typhimurium isolate contained blaSHV-12; the Mbandaka isolate contained blaSHV-30. Nine Senftenberg isolates contained blaOXA-1; 1 contained blaOXA-9. Further studies should address patient outcomes, risk factors, and resistance dissemination prevention strategies.
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Human Salmonella and Concurrent Decreased Susceptibility to Quinolones and Extended-Spectrum Cephalosporins
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Autor/in / Beteiligte Person: | Whichard, Jean M. ; Gay, Kathryn ; Stevenson, Jennifer E. ; Joyce, Kevin J. ; Cooper, Kara L. ; Omondi, Michael ; Medalla, Felicita ; Jacoby, George A. ; Barrett, Timothy J. |
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Zeitschrift: | Emerging Infectious Diseases, Jg. 13 (2007), Heft 11, S. 1681-1688 |
Veröffentlichung: | Centers for Disease Control and Prevention, 2007 |
Medientyp: | academicJournal |
ISSN: | 1080-6040 (print) ; 1080-6059 (print) |
DOI: | 10.3201/eid1311.061438 |
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