Cardiovascular outcomes with sodium–glucose cotransporter-2 inhibitors vs other glucose-lowering drugs in 13 countries across three continents: analysis of CVD-REAL data
In: Cardiovascular Diabetology, Jg. 20 (2021), Heft 1, S. 1-15
Online
academicJournal
Zugriff:
Abstract Background Randomized, controlled cardiovascular outcome trials may not be fully representative of the management of patients with type 2 diabetes across different geographic regions. We conducted analyses of data from the multinational CVD-REAL consortium to determine the association between initiation of sodium–glucose cotransporter-2 inhibitors (SGLT-2i) and cardiovascular outcomes, including subgroup analyses based on patient characteristics. Methods De-identified health records from 13 countries across three continents were used to identify patients newly-initiated on SGLT-2i or other glucose-lowering drugs (oGLDs). Propensity scores for SGLT-2i initiation were developed in each country, with 1:1 matching for oGLD initiation. In the matched groups hazard ratios (HRs) for hospitalization for heart failure (HHF), all-cause death (ACD), the composite of HHF or ACD, myocardial infarction (MI) and stroke were estimated by country, and pooled using a weighted meta-analysis. Multiple subgroup analyses were conducted across patient demographic and clinical characteristics to examine any heterogeneity in treatment effects. Results Following matching, 440,599 new users of SGLT-2i and oGLDs were included in each group. Mean follow-up time was 396 days for SGLT-2i initiation and 406 days for oGLDs initiation. SGLT-2i initiation was associated with a lower risk of HHF (HR: 0.66, 95%CI 0.58–0.75; p
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Cardiovascular outcomes with sodium–glucose cotransporter-2 inhibitors vs other glucose-lowering drugs in 13 countries across three continents: analysis of CVD-REAL data
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Autor/in / Beteiligte Person: | Khunti, Kamlesh ; Kosiborod, Mikhail ; Dae Jung Kim ; Kohsaka, Shun ; Lam, Carolyn S. P. ; Goh, Su-Yen ; Chiang, Chern-En ; Shaw, Jonathan E. ; Cavender, Matthew A. ; Tangri, Navdeep ; Franch-Nadal, Josep ; Holl, Reinhard W. ; Jørgensen, Marit E. ; Norhammar, Anna ; Eriksson, Johan G. ; Zaccardi, Francesco ; Karasik, Avraham ; Magliano, Dianna J. ; Thuresson, Marcus ; Chen, Hungta ; Wittbrodt, Eric ; Bodegård, Johan ; Surmont, Filip ; Fenici, Peter ; the CVD-REAL Investigators and Study Group |
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Zeitschrift: | Cardiovascular Diabetology, Jg. 20 (2021), Heft 1, S. 1-15 |
Veröffentlichung: | BMC, 2021 |
Medientyp: | academicJournal |
ISSN: | 1475-2840 (print) |
DOI: | 10.1186/s12933-021-01345-z |
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