Implications of isolated white matter abnormalities on neonatal MRI in congenital CMV infection: a prospective single-centre study
In: BMJ Paediatrics Open, Jg. 7 (2023-12-01), Heft 1
Online
academicJournal
Zugriff:
Objective Investigating the clinical implications of isolated white matter abnormalities on neonatal brain MRI in congenital cytomegalovirus (CMV).Design Prospective, observational.Patients/interventions Two paediatric radiologists, blinded to clinical data, independently scored the white matter in 286 newborns with congenital CMV. After assessing interobserver variability, mean score was used to categorise white matter (normal, doubtful or abnormal). Patients with other brain abnormalities were excluded.Main outcome measures Hearing and neuromotor evaluation.Results Cohen’s weighted kappa was 0.79 (95% CI 0.73 to 0.84). White matter was normal in 121 patients, doubtful in 62, abnormal in 28. Median clinical follow-up was 12.0 months (IQR 12.0–27.7 months). Neonatal hearing loss occurred in 4/27 patients (14.8%) with abnormal, 1/118 patients (0.8%) with normal and 1/62 patients (1.6%) with doubtful white matter (p
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Implications of isolated white matter abnormalities on neonatal MRI in congenital CMV infection: a prospective single-centre study
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Autor/in / Beteiligte Person: | Herregods, Nele ; Oostra, Ann ; Caroline Vande Walle ; Keymeulen, Annelies ; Schiettecatte, Eva ; Ingeborg Johanna Dhooge ; Smets, Koenraad |
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Zeitschrift: | BMJ Paediatrics Open, Jg. 7 (2023-12-01), Heft 1 |
Veröffentlichung: | BMJ Publishing Group, 2023 |
Medientyp: | academicJournal |
ISSN: | 2399-9772 (print) |
DOI: | 10.1136/bmjpo-2023-002097 |
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