PKZ, a Fish-Unique eIF2α Kinase Involved in Innate Immune Response
In: Frontiers in Immunology, Jg. 11 (2020-03-01)
Online
academicJournal
Zugriff:
PKZ is a novel and unique eIF2α protein kinase identified in fish. Although PKZ is most homologous to PKR, particularly in the C-terminal catalytic domain, it contains two N-terminal Z-DNA-binding domains (Zα1 and Zα2) instead of the dsRNA binding domains (dsRBDs) in PKR. As a novel member of eIF2α kinase family, the available data suggest that PKZ has some distinct mechanisms for recognition, binding, and B-Z DNA transition. Functionally, PKZ seems to be activated by the binding of Zα to Z-DNA and participates in innate immune responses. In this review, we summarize the recent progress on fish PKZ.
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PKZ, a Fish-Unique eIF2α Kinase Involved in Innate Immune Response
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Autor/in / Beteiligte Person: | Wu, Chuxin ; Zhang, Yibing ; Hu, Chengyu |
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Zeitschrift: | Frontiers in Immunology, Jg. 11 (2020-03-01) |
Veröffentlichung: | Frontiers Media S.A., 2020 |
Medientyp: | academicJournal |
ISSN: | 1664-3224 (print) |
DOI: | 10.3389/fimmu.2020.00585 |
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