Nanoparticle-based drug delivery systems: What can they really do in vivo? [version 1; referees: 3 approved]

Wang, Yi-Feng ; Liu, Lu ; et al.

In: F1000Research, Jg. 6 (2017-05-16), S. F1000 Faculty Rev-681

Online academicJournal

Zugriff:

In the past few decades, there has been explosive growth in the construction of nanoparticle-based drug delivery systems (NDDSs), namely nanomedicines, owing to their unique properties compared with traditional drug formulations. However, because of a variety of challenges, few nanomedicines are on sale in the market or undergoing clinical trial at present. Thus, it is essential to look back and re-evaluate what these NDDSs can really do in vivo, why nanomedicines are regarded as potential candidates for next-generation drugs, and what the future of nanomedicine is. Here, we focus mainly on the properties of NDDSs that extend blood circulation, enhance penetration into deep tumor tissue, enable controllable release of the payload into the cytoplasm, and overcome multi-drug resistance. We further discuss how to promote the translation of nanomedicines into reality. This review may help to identify the functions of NDDSs that are really necessary before they are designed and to reduce the gap between basic research and clinical application.

Titel:	Nanoparticle-based drug delivery systems: What can they really do in vivo? [version 1; referees: 3 approved]
Autor/in / Beteiligte Person:	Wang, Yi-Feng ; Liu, Lu ; Xue, Xue ; Liang, Xing-Jie
Link:	View record at F1000Research (Volltext)
Zeitschrift:	F1000Research, Jg. 6 (2017-05-16), S. F1000 Faculty Rev-681
Veröffentlichung:	London, UK: F1000 Research Limited, 2017
Medientyp:	academicJournal
ISSN:	2046-1402 (print)
DOI:	10.12688/f1000research.9690.1
Schlagwort:	Review Articles Biocatalysis Biomacromolecule-Ligand Interactions Biomimetic Chemistry Cancer Therapeutics Drug Discovery & Design Macromolecular Chemistry Molecular Pharmacology Pharmacokinetics & Drug Delivery nanoparticles drug delivery efficiency biocompatilbility
Sonstiges:	Nachgewiesen in: F1000Research Document Type: review Author Affiliations: 1 = Laboratory of Controllable Nanopharmaceuticals, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China ; 2 = University of Chinese Academy of Sciences, Beijing, 100049, China Rights: Copyright: © 2017 Wang YF et al. Notes: Editorial Note on the Review Process F1000 Faculty Reviews are commissioned from members of the prestigious F1000 Faculty and are edited as a service to readers. In order to make these reviews as comprehensive and accessible as possible, the referees provide input before publication and only the final, revised version is published. The referees who approved the final version are listed with their names and affiliations but without their reports on earlier versions (any comments will already have been addressed in the published version). The referees who approved this article are: Xiaoyuan (Shawn) Chen, Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB) and National Institutes of Health (NIH), Bethesda, Maryland, USA No competing interests were disclosed. Zhen Gu, Department of Biomedical Engineering, UNC Eshelman Pharmacy School, University of North Carolina at Chapel Hill, NC, USA No competing interests were disclosed. Kenneth A. Dawson, Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dublin, Dublin, Ireland No competing interests were disclosed. ; [version 1; referees: 3 approved]

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