NPY leu7pro and alcohol dependence in Finnish and Swedish populations
In: Alcoholism, clinical and experimental research, Jg. 27 (2003), Heft 1, S. 19-24
Online
academicJournal
- print; 6; 32 ref
Zugriff:
Background: Neuropeptide Y (NPY) is a modulator of alcohol intake in animal models of alcoholism, and is potentially involved in alcohol dependence. A coding Leu7Pro polymorphism in the signal peptide of preproNPY has been described, and the Pro7 allele has been reported to correlate with increased alcohol consumption in non-dependent Finnish males. Recently, this polymorphism was also reported to be associated with an actual diagnosis of alcohol dependence. Methods: We compared Pro7 allele frequencies in one Finnish (n = 135) and one Swedish (n = 472) population of alcohol dependent individuals, and ethnically matched controls (Finns: n = 213; Swedes: n = 177) in whom alcohol dependence was established, or any diagnosis of substance disorder was excluded, respectively, through the use of structured face-to-face interviews. Results: Pro7 frequencies in alcoholics were 5.2 and 4.1% in Finns and Swedes, respectively, similar to the 5.0-5.5% recently reported in European Americans in a Yale study. However, corresponding frequencies in the control populations were similar, at 6.1 and 5.9% in Finns and Swedes, respectively, yielding no association, in contrast with the Yale study, where an association was reported based on a 2.0% Pro7 frequency in European American controls. A meta-analysis of available data yields Pro7 frequencies of 4.7% both in Caucasian alcoholics and Caucasian controls. Conclusions: Pro7 does not seem to be associated with a diagnosis of alcoholism in Caucasian populations.
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NPY leu7pro and alcohol dependence in Finnish and Swedish populations
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Autor/in / Beteiligte Person: | GUANSHAN, ZHU ; POLLAK, Lotta ; MOTTAGUI-TABAR, Salim ; WAHLESTEDT, Claes ; TAUBMAN, Julie ; VIRKKUNEN, Matti ; GOLDMAN, David ; HELLIG, Markus |
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Zeitschrift: | Alcoholism, clinical and experimental research, Jg. 27 (2003), Heft 1, S. 19-24 |
Veröffentlichung: | Baltimore, MD: Lippincott Williams & Wilkins, 2003 |
Medientyp: | academicJournal |
Umfang: | print; 6; 32 ref |
ISSN: | 0145-6008 (print) |
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