Olfactory associative learning in caenorhabditis elegans is impaired in lrn-1 and lrn-2 mutants
In: Behavioral neuroscience, Jg. 113 (1999), Heft 2, S. 358-367
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Zugriff:
The C. elegans mutants, lrn- and lrn-2, are impaired in associative learning using conditioned taste cues. Both mutants are defective in associative learning about appetitive and aversive events, indicating that lrn-1 and lrn-2 exert effects across motivational boundaries. In a new olfactory associative learning paradigm, in which wild type worms learn to avoid a previously attractive diacetyl odor after it has been paired with an aversive acetic acid solution, lrn-1 and lrn-2 are impaired. Although defective in associative learning using a conditioned olfactory cue, nonassociative learning (habituation and dishabituation) using this same olfactory cue is unaffected. The discovery that lrn-1 and lrn-2 are defective in associative learning with both taste and olfactory cues may suggest that associative learning in different sensory modalities converges on a common genetic pathway in C. elegans that is subserved by lrn-1 and lrn-2.
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Olfactory associative learning in caenorhabditis elegans is impaired in lrn-1 and lrn-2 mutants
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Autor/in / Beteiligte Person: | MORRISON, G. E ; WEN, J. Y. M ; RUNCIMAN, S ; VAN DER KOOV, D |
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Zeitschrift: | Behavioral neuroscience, Jg. 113 (1999), Heft 2, S. 358-367 |
Veröffentlichung: | Washington, DC: American Psychological Association, 1999 |
Medientyp: | academicJournal |
Umfang: | print; 20 ref |
ISSN: | 0735-7044 (print) |
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